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Vesicoureteral reflux and the extracellular matrix connection

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Abstract

Primary vesicoureteral reflux (VUR) is a common pediatric condition due to a developmental defect in the ureterovesical junction. The prevalence of VUR among individuals with connective tissue disorders, as well as the importance of the ureter and bladder wall musculature for the anti-reflux mechanism, suggest that defects in the extracellular matrix (ECM) within the ureterovesical junction may result in VUR. This review will discuss the function of the smooth muscle and its supporting ECM microenvironment with respect to VUR, and explore the association of VUR with mutations in ECM-related genes.

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Authors and Affiliations

  1. Department of Human Genetics, McGill University, Montreal, QC, Canada

    Fatima Tokhmafshan & Indra R. Gupta

  2. Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, IA, 52242, USA

    Patrick D. Brophy

  3. Department of Pediatrics, Division of Nephrology, Duke University Medical Center, Durham, NC, 27710, USA

    Rasheed A. Gbadegesin

  4. Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA

    Rasheed A. Gbadegesin

  5. Department of Pediatrics, McGill University, Montreal, QC, Canada

    Indra R. Gupta

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  1. Fatima Tokhmafshan
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Tokhmafshan, F., Brophy, P.D., Gbadegesin, R.A. et al. Vesicoureteral reflux and the extracellular matrix connection. Pediatr Nephrol 32, 565–576 (2017). https://doi.org/10.1007/s00467-016-3386-5

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