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Promoting calcium and vitamin D intake to reduce the risk of osteoporosis in men on androgen deprivation therapy for recurrent prostate cancer

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Abstract

Purpose

The aim of this study was to measure the impact of a patient education intervention aimed at increasing dietary intake of calcium and vitamin D in patients currently on androgen deprivation therapy (ADT) for the treatment of prostate cancer.

Methods

Sixty-one participants attended a one-time dietitian-delivered group education session focusing on diet and lifestyle strategies to reduce the risk of bone loss while on ADT. Dietary intake was assessed using the diet history questionnaire at baseline and again at approximately 1 year post-intervention. Demographics, medical history (including comorbidities), awareness of developing bone loss while on ADT, and information resources utilized were recorded at baseline.

Results

Fifty-one participants completed both time points. Over one third of men did not meet minimum current clinical guidelines for calcium or vitamin D intake at baseline. Sixty-three percent of men reported they were aware that osteoporosis was a known side effect of ADT therapy. Only supplemental calcium intake was significantly increased after the intervention. Men aware of their risk of developing bone loss while on ADT reported higher baseline calcium intake (p ≤ 0.05). Men undergoing ADT for less than 1 year at the time of intervention had significantly higher total calcium intake at follow-up compared to men on ADT for longer than 1 year (p = 0.038). Nonsignificant trends indicated that calcium and vitamin D intakes changed to a greater degree in those undergoing ADT for less than 1 year as well.

Conclusions

Total calcium and vitamin D did not change significantly as a result of the intervention. Results suggest that promotion of dietary changes may be more effective if delivered closer to the initiation of therapy.

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Acknowledgments

Funds for this study were provided by the British Columbia Foundation for Prostate Disease. Sincere thanks to Drs. Larry Goldenberg, Martin Gleave, and Alan So for assistance in patient recruitment. We are also grateful to Erin Breckon and Morag Yule who assisted in data collection and data management.

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Authors and Affiliations

  1. College of Nursing, University of Saskatchewan, #310-1121 College Drive, Saskatoon, SK S7N 0 W3, Canada

    B. Joyce Davison

  2. Mount Royal University, Calgary, AB, Canada

    Kristin Wiens

  3. Vancouver Prostate Centre, Vancouver, BC, Canada

    Meredith Cushing

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  1. B. Joyce Davison
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  2. Kristin Wiens
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  3. Meredith Cushing
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Correspondence to B. Joyce Davison.

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Davison, B.J., Wiens, K. & Cushing, M. Promoting calcium and vitamin D intake to reduce the risk of osteoporosis in men on androgen deprivation therapy for recurrent prostate cancer. Support Care Cancer 20, 2287–2294 (2012). https://doi.org/10.1007/s00520-011-1331-5

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  • DOI: https://doi.org/10.1007/s00520-011-1331-5

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