Abstract
Purpose
The purpose of this study was to develop a Japanese version of hand-foot syndrome (HFS)-specific quality of life (QOL) questionnaire (HFS-14) to evaluate and monitor the QOL of patients with a possibility of HFS.
Methods
The original English version of HFS-14 was translated and slightly modified into Japanese, and the Japanese HFS-14 was administered to 187 patients receiving chemotherapy with high risk of developing HFS as outpatients in four institutions in Japan. Factor validity, internal consistency, correlation with the Skindex-16 and Dermatology Life Quality Index (DLQI) scores, known group validity, and test-retest reliability were analyzed for 105 patients who developed HFS. Next, we compared HFS-14 with DLQI and Skindex-16.
Results
Factor analysis confirmed the factor structure (one putative scale) of the Japanese HFS-14. Cronbach’s alpha was over 0.90. The Japanese HFS-14 score was correlated with the Skindex-16 and DLQI score. Intra-class correlation coefficients were over 0.80. Patients with severe HFS reported significantly poorer HFS-14 score than those with mild HFS. The Skindex-16 and DLQI scores were also significantly different in patients with different Common Terminology Criteria for Adverse Events (CTCAE) grades, but with smaller effect sizes than those for the HFS-14 score.
Conclusions
The Japanese HFS-14 provides a valid and reliable score for monitoring and evaluating HFS.
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Acknowledgments
This work was supported in part by a Third Term Comprehensive Control Research for Cancer fund from the Japanese Ministry of Health, Labour and Welfare [grant number 22092401]. The authors thank all the patients who took part in the study. The authors also thank Hiroyasu Esumi for his support.
Conflict of interest
The authors did not have any potential conflicts of interest in the research reported.
Financial support
This study was supported by a research group funded by the Ministry of Health, Labour and Welfare, Japan.
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Mikoshiba, N., Yamamoto-Mitani, N., Sato, K. et al. Validation of the Japanese version of HFS-14, a disease-specific quality of life scale for patients suffering from hand-foot syndrome. Support Care Cancer 23, 2739–2745 (2015). https://doi.org/10.1007/s00520-015-2638-4
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DOI: https://doi.org/10.1007/s00520-015-2638-4