Abstract
Purpose
To determine the effect of interpersonal psychotherapy on anxiety, depression, and quality of life among breast cancer patients with mental health disorders at Tikur Anbessa Specialized Hospital, Ethiopia.
Methods
A two-arm parallel randomized controlled trial study was conducted among 114 (n = 57 intervention, and n = 57 control group) breast cancer patients with common mental health disorder at the oncology center of Tikur Anbessa Specialized Hospital. The hospital anxiety and depression measurement scale was used to assess depression and anxiety disorder and a 30-item quality of life questionnaire was used to assess the quality of life. General linear model analysis was done, confounding factors were controlled, and p < 0.05 was used to declare statistical significance.
Results
Patients in the intervention group showed a significant improvement in the anxiety (coefficient − 3.68; 95% CI − 5.67, − 1.69; p < 0.001), depression (coefficient − 3.22; 95% CI − 4.7, − 1.69; p < 0.001), physical functioning (coefficient 10.55; 95% CI 3.13, 17.98; p = 0.006), health-related quality of life (coefficient 21.85; 95% CI 14.1, 29.59; p < 0.001), insomnia (coefficient − 19.56; 95% CI − 31.87, − 7.25; p = 0.002), and fatigue (coefficient − 11.37; 95% CI − 21.49, − 1.24; p = 0.028) respectively.
Conclusions
The adapted Ethiopian version of interpersonal psychotherapy had improved anxiety, depression, and some domains of health-related quality of life. Hence, health programmers should consider incorporating it as a treatment option in oncology centers.
Trial registration number
PACTR202011629348967 granted on 20 November 2020 which was retrospectively registered.
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Data availability
The datasets generated and analyzed during the current study are available from the corresponding author on a reasonable request.
Code availability
All data generated or analyzed during the study are included in this manuscript.
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–49
Sharma R (2020) Breast cancer burden in Africa: evidence from GLOBOCAN 2018. Journal of Public Health
Memirie ST, Habtemariam MK, Asefa M, Deressa BT, Abayneh G, Tsegaye B et al (2018) Estimates of cancer incidence in Ethiopia in 2015 using population-based registry data. J Glob Oncol 4:1–11
Areri HA, Shibabaw W, Mulugeta T, Asmare Y, Yirga T (2019) Survival status and predictors of mortality among breast cancer patients in Adult Oncology Unit at Black Lion Specialized Hospital, Addis Ababa, Ethiopia, 2018. bioRxiv 636431
Yang Y-L (2014) Prevalence and associated positive psychological variables of depression and anxiety among chinese cervical cancer patients: a cross-sectional study. PloS one 9(4)
Association AP (2013) Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub
Nuhu FT, Adebayo KO, Adejumo O (2013) Quality of life of people with cancers in Ibadan. Nigeria Journal of Mental Health 22(4):325–333
House DSA (2000) DPH Stark1 and A House2. Br J Cancer 83(10):1261–7
Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE et al (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. The Lancet 382(9904):1575–1586
B.Sc.Tech JLMSTaHV. Patient-reported outcome measures in cancer care: a review of the scientific evidence
Badger TA, Segrin C, Hepworth JT, Pasvogel A, Weihs K, Lopez AM (2013) Telephone-delivered health education and interpersonal counseling improve quality of life for Latinas with breast cancer and their supportive partners. Psychooncology 22(5):1035–1042
Levy KN, Ehrenthal JC, Yeomans FE, Caligor E (2014) The efficacy of psychotherapy: focus on psychodynamic psychotherapy as an example. Psychodynamic Psychiatry 42(3):377–421
Wojtyna E, Życińska J, Stawiarska P (2007) The influence of cognitive-behaviour therapy on quality of life and self-esteem in women suffering from breast cancer. Reports of Practical Oncology & Radiotherapy 12(2):109–117
Blanco CMJ, Hershman DL et al (2014) A pilot study of interpersonal psychotherapy for depressed women with breast cancer. Am J Psychother 2014(68):489–495
Gelaye B, Williams MA, Lemma S, Deyessa N, Bahretibeb Y, Shibre T et al (2013) Validity of the patient health questionnaire-9 for depression screening and diagnosis in East Africa. Psychiatry Res 210(2):653–661
Berihun F, Haile S, Abawa M, Mulatie M, Shimeka A (2017) Prevalence and correlates of anxiety and depression among cancer patients in the University of Gondar comprehensive specialized hospital, Northwest Ethiopia. Archives of Depression and Anxiety 3(2):42–48
Alemayehu M, Deyessa N, Medihin G, Fekadu A (2018) A descriptive analysis of depression and pain complaints among patients with cancer in a low income country. PloS one. 13(3):e0193713
Pain C, Wondimagegn D, Alem A, Ravitz P, Frank E, Nelson S, et al (2013) The Biaber Project scaling up Interpersonal Psychotherapy (IPT) for common mental disorders in Ethiopia. Ethiopia, Grand Challenges
Reda AA (2011) Reliability and validity of the Ethiopian version of the hospital anxiety and depression scale (HADS) in HIV infected patients. PLoS One. 6(1):e16049
Snaith RP (2003) The hospital anxiety and depression scale. Health Qual Life Outcomes 1(1):1–4
Ayana BA, Negash S, Yusuf L, Tigeneh W, Haile D (2016) Reliability and validity of amharic version of EORTC QLQ-C 30 questionnaire among gynecological cancer patients in Ethiopia. PloS one. 11(6):e0157359
Fayers PM, Aaronson NK, Bjordal K, Curran D, Grønvold M (1999) EORTC QLQ-C30 scoring manual: Eortc
Osborn RL, Demoncada AC, Feuerstein M (2006) Psychosocial interventions for depression, anxiety, and quality of life in cancer survivors: meta-analyses. The International Journal of Psychiatry in Medicine 36(1):13–34
Goerling U, Foerg A, Sander S, Schramm N, Schlag PM (2011) The impact of short-term psycho-oncological interventions on the psychological outcome of cancer patients of a surgical-oncology department–a randomised controlled study. Eur J Cancer 47(13):2009–2014
Dolbeault S, Cayrou S, Bredart A, Viala A, Desclaux B, Saltel P et al (2009) The effectiveness of a psycho-educational group after early-stage breast cancer treatment: results of a randomized French study. Psychooncology. 18(6):647–56
Srivastava V, Ansari M, Kumar A (2017) Factors affecting anxiety and depression among breast cancer patients: a study from northern India. Eur J Cancer 72:S163
Brix C, Schleussner C, Füller J, Roehrig B, Wendt TG, Strauss B (2008) The need for psychosocial support and its determinants in a sample of patients undergoing radiooncological treatment of cancer. J Psychosom Res 65(6):541–548
Asuzu CC, Akin-Odanye EO, Philip EJ (2016) The effect of pilot cognitive restructuring therapy intervention on depression in female cancer patients. Psychooncology 25(6):732–736
Park J-H, Bae SH, Jung YS, Kim KS (2012) Quality of life and symptom experience in breast cancer survivors after participating in a psychoeducational support program: a pilot study. Cancer Nurs 35(1):E34–E41
Sherman DW, Haber J, Hoskins CN, Budin WC, Maislin G, Shukla S et al (2012) The effects of psychoeducation and telephone counseling on the adjustment of women with early-stage breast cancer. Appl Nurs Res 25(1):3–16
Guo Z, Tang H-Y, Li H, Tan S-K, Feng K-H, Huang Y-C et al (2013) The benefits of psychosocial interventions for cancer patients undergoing radiotherapy. Health and quality of life outcomes. 11(1):121
Chaar EA, Hallit S, Hajj A, Aaraj R, Kattan J, Jabbour H et al (2018) Evaluating the impact of spirituality on the quality of life, anxiety, and depression among patients with cancer: an observational transversal study. Support Care Cancer 26(8):2581–2590
Winnie K.W. So P, MHA, BN, RN (2010) Anxiety, depression and quality of life among Chinese breast cancer patients during adjuvant therapy. European Journal of Oncology Nursing 17–22.
Carlson LE, Speca M, Patel KD, Goodey E (2004) Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology 29(4):448–474
Carlson LE, Garland SN (2005) Impact of mindfulness-based stress reduction (MBSR) on sleep, mood, stress and fatigue symptoms in cancer outpatients. Int J Behav Med 12(4):278–285
Lengacher CA, Reich RR, Paterson CL, Jim HS, Ramesar S, Alinat CB et al (2015) The effects of mindfulness-based stress reduction on objective and subjective sleep parameters in women with breast cancer: a randomized controlled trial. Psychooncology 24(4):424–432
Johns SA, Brown LF, Beck-Coon K, Monahan PO, Tong Y, Kroenke K (2015) Randomized controlled pilot study of mindfulness-based stress reduction for persistently fatigued cancer survivors. Psychooncology 24(8):885–893
Tabrizi FM, Radfar M, Taei Z (2016) Effects of supportive-expressive discussion groups on loneliness, hope and quality of life in breast cancer survivors: a randomized control trial. Psychooncology 25(9):1057–1063
Adler NE, Newman K (2002) Socioeconomic disparities in health: pathways and policies. Health Aff 21(2):60–76
Cassedy A, Drotar D, Ittenbach R, Hottinger S, Wray J, Wernovsky G et al (2013) The impact of socio-economic status on health related quality of life for children and adolescents with heart disease. Health Qual Life Outcomes 11(1):1–8
Acknowledgements
We are very much grateful to the participants and clinical psychologists for their willingness to participate in this study.
Funding
This study was funded by the Addis Ababa University, school of public health and female Cancer initiative funding, Bristol Myers through CORDAID. The funder had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript (project number: 113305.002).
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Conceptualization: Winini Belay, Werissaw Haileselassie; methodology: Winini Belay, Mirgissa kaba, Wajana Lako, Wondemagegnehu Tigeneh, Werissaw Haileselassie, Abebe Ejigu; formal analysis and investigation: Winini Belay, Zekariyas Sahile, Werissaw Haileselassie, Wajana Lako, Wondemagegnehu Tigeneh, Mirgissa Kaba; writing—original draft preparation: Winini Belay, Werissaw Haileselassie; writing—review and editing: Mirgissa kaba, Wajana Lako, Wondemagegnehu Tigeneh, Yonas Baheretibeb, Zenawi Hagos Gufue, Abebe Ejigu, Ababi Zergaw; supervision: Winini Belay, Mirgissa kaba, Werissaw Haileselassie, Wajana Lako, Wondemagegnehu Tigeneh, Mirgissa Kaba; project administration: Winini Belay, Werissaw Haileselassie; validation: Winini Belay, Zekariyas Sahile, Werissaw Haileselassie, Yonas Baheretibebe; visualization: Winini Belay, Zekariyas Sahile, Wajana Lako; resources: Wajana Lako, Werissaw Haileselassie, Mirgissa Kaba, Wondemagegnehu Tigeneh.
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This study was performed in line with the principles of the Declaration of Helsinki. Ethical approval was obtained from the institutional review board of the school of public health, Addis Ababa University (SPH/004/2019).
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The participants gave consent to participate in the study through informed written consent.
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The authors declare no competing interests.
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Belay, W., kaba, M., Labisso, W.L. et al. The effect of interpersonal psychotherapy on quality of life among breast cancer patients with common mental health disorder: a randomized control trial at Tikur Anbessa Specialized Hospital. Support Care Cancer 30, 965–972 (2022). https://doi.org/10.1007/s00520-021-06508-y
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DOI: https://doi.org/10.1007/s00520-021-06508-y