Abstract
Surgical resection, considered the optimal treatment of biliary papillomatosis, often remains incomplete due to high risk of recurrence in view of positive margins or recurrence on the remnant bile duct because of its multifocality. Resection of the whole biliary tree by liver transplantation and duodenopancreatectomy can be regarded as the only curative treatment. However, this approach has resulted in unfavorable results in patients with advanced tumor invasion and/or positive lymph nodes. For the majority of biliary tumors, preoperative assessment is often insufficient. Therefore, we advocate initial partial resection as a first step to eliminate both advanced tumor invasion and/or positive lymph nodes on definitive analysis of the specimen. We propose the strategy of initial resection for selecting the patients who would actually benefit from liver transplantation.
Similar content being viewed by others
References
Adbores-Saavedra J, Scoazec JC, Wittekind C, Sripa B, Menck HR, Soehendra N, et al. Carcinoma of the gallbladder and extrahepatic bile ducts. In: Hamilton Sr, Aaltonen La, editors. Lyon: IARC Press; 2000.
Zen Y, Fujii T, Itatsu K, Nakamura K, Minato H, Kasashima S, et al. Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology. 2006;44:1333–43.
Lee SS, Kim MH, Lee SK, Jang SJ, Song MH, Kim KP, et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 2004;100:783–93.
Nakanishi Y, Zen Y, Kondo S, Itoh T, Itatsu K, Nakanuma Y. Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm. Hum Pathol. 2008;39:1153–61.
Yeh TS, Tseng JH, Chiu CT, Liu NJ, Chen TC, Jan YY, et al. Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts. Ann Surg. 2006;244:248–53.
Jang KT, Hong SM, Lee KT, Lee JG, Choi SH, Heo JS, et al. Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection. Virchows Arch. 2008;453:589–98.
Chen TC, Nakanuma Y, Zen Y, Chen MF, Jan YY, Yeh TS, et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology. 2001;34:651–8.
Lee PS, Auyeung KM, To KF, Chan YI. Biliary papillomatosis complicating recurrent pyogenic cholangitis. Clin Radiol. 2001;56:591–3.
Igami T, Nagino M, Oda K, Nishio H, Ebata T, Yokoyama Y, et al. Clinicopathologic study of cholangiocarcinoma with superficial spread. Ann Surg. 2009;249:296–302.
Vassiliou I, Kairi-Vassilatou E, Marinis A, Theodosopoulos T, Arkadopoulos N, Smyrniotis V. Malignant potential of intrahepatic biliary papillomatosis: a case report and review of the literature. World J Surg Oncol. 2006;4:71.
Charre L, Boillot O, Goffette P, Geubel A, Gigot JF, Sempoux C, et al. Long-term survival after isolated liver transplantation for intrahepatic biliary papillomatosis. Transpl Int. 2006;19:249–52.
Beavers KL, Fried MW, Johnson MW, Zacks SL, Gerber DA, Weeks SM, et al. Orthotopic liver transplantation for biliary papillomatosis. Liver Transpl. 2001;7:264–6.
Dumortier J, Scoazec JY, Valette PJ, Ponchon T, Boillot O. Successful liver transplantation for diffuse biliary papillomatosis. J Hepatol. 2001;35:542–3.
Ciardullo MA, Pekolj J, Acuna Barrios JE, Gadano A, Mullen E, Castaing D, et al. Multifocal biliary papillomatosis: an indication for liver transplantation. Ann Chir. 2003;128:188–90.
Gigot JF, Geubel A, Haot J. Papillomatose des voies biliaires. Acta Endoscopica. 1989;19:345.
Bottger TH, Sorger K, Jenny E, Junginger TH. Progressive papillomatosis of the intrahepatic and extrahepatic bile ducts. Acta Chir Scand. 1989;155:125.
Jiang L, Yan LN, Jiang LS, Li FY, Ye H, Li N, et al. Biliary papillomatosis: analysis of 18 cases. Chin Med J. 2008;121:2610–2.
Hwang S, Lee SG, Kim KH, Ahn CS, Moon DB, Ha TY, et al. Extended extrahepatic bile duct resection to avoid performing pancreatoduodenectomy in patients with mid bile duct cancer. Dig Surg. 2008;25:74–9.
Kim JK, Hwang HK, Park JS, Cho SI, Yoon DS, Chi HS. Left hemihepatectomy and caudate lobectomy and complete extrahepatic bile duct resection using transduodenal approach for hilar cholangiocarcinoma arsing from biliary papillomatosis. J Surg Oncol. 2008;98:139–42.
Wakai T, Shirai Y, Tsuchiya Y, Nomura T, Akazawa K, Hatakeyama K. Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term results. World J Surg. 2008;32:1067–74.
Marion-Audibert AM, Guillet M, Rode A, Barnoud R, Mesnil A, Ducerf C, et al. Diffuse biliary papillomatosis: a rare indication for liver transplantation. Gastroenterol Clin Biol. 2009;33:82–5.
Brugge WR. Endoscopic techniques to diagnose and manage biliary tumors. J Clin Oncol. 2005;23:4561–5.
Weber A, von Weyhern C, Fend F, Schneider J, Neu B, Meining A, et al. Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma. World J Gastroenterol. 2008;14:1097–101.
Fridell JA, Vianna R, Mangus RS, Kazimi M, Hollinger E, Joseph Tector A. Addition of a total pancreatectomy and pancreas transplantation in a liver transplant recipient with intraductal papillary mucinous neoplasm of the pancreas. Clin Transplant. 2008;22:681–4.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Vibert, E., Dokmak, S. & Belghiti, J. Surgical strategy of biliary papillomatosis in Western countries. J Hepatobiliary Pancreat Sci 17, 241–245 (2010). https://doi.org/10.1007/s00534-009-0151-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00534-009-0151-1