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Eosinophilic gastroenteritis: a review

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Abstract

Eosinophilic gastroenteritis is a clinicopathological disease affecting both children and adults that is characterized by patchy or diffuse eosinophilic infiltration of the gastrointestinal tract with variable resultant clinical gastrointestinal manifestations. The eosinophil, eotaxin, and Th-2 cytokines are important in pathogenesis of this disease entity. It may be confused with parasitic and bacterial infections (including Helicobacter pylori), inflammatory bowel disease, hypereosinophilic syndrome, myeloproliferative disorders, periarteritis, allergic vasculitis, scleroderma, drug injury, and drug hypersensivity. Obtaining the correct diagnosis is important, and a pathologist usually makes this distinction. Effective treatments include systemic/topical corticosteroids, specific food elimination or an elemental diet, certain drugs, and even surgery. A variety of new therapeutic approaches are now under trial.

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References

  1. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 2004;113:11–28.

    Article  PubMed  CAS  Google Scholar 

  2. Kaijser R. Allergic disease of the gut from the point of view of the surgeon. Arch Klin Chir 1937;188:36–64.

    Google Scholar 

  3. Ureles AL, Alschibaja T, Lodico L, Stabins SJ. Idiopathic eosinophilic infiltration of the gastrointestinal tract, diffuse and circumscribed. A proposed classification and review of the literature, with two additional cases. Am J Med 1961;30:898–909.

    Article  Google Scholar 

  4. Klein NC, Hargrove RL, Sleisenger MH, Jeffries GH. Eosinophilic gastroenteritis. Medicine (Baltim) 1970;40:299–319.

    Google Scholar 

  5. Oyaizu N, Uemura Y, Izumi H, Morii S, Nishi M, Hioki K. Eosinophilic gastroenteritis, immunohistochemical evidence for IgE mast cell mediated allergy. Acta Pathol Jpn 1985;35:759–766.

    PubMed  CAS  Google Scholar 

  6. Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer and subserosal tissues. Gut 1990;31:54–58.

    Article  PubMed  CAS  Google Scholar 

  7. Gleich GJ, Loegering DA. Immunobiology of eosinophils. Annu Rev Immunol 1984;2:429–459.

    Article  PubMed  CAS  Google Scholar 

  8. Weller PF. Eosinophils: structure and functions. Curr Opin Immunol 1994;6:8590.

    Article  Google Scholar 

  9. Rothenberg ME. Eosinophilia. N Engl J Med 1998;338:1592–1600.

    Article  PubMed  CAS  Google Scholar 

  10. Jay V. Paul Ehrlich. Arch Pathol Lab Med 2001;125:724–725.

    PubMed  CAS  Google Scholar 

  11. Boyce JA, Friend D, Matsumoto R, Austen KF, Owen WF. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate. J Exp Med 1995;182:49–57.

    Article  PubMed  CAS  Google Scholar 

  12. McNagny K, Graf T. Making eosinophils through subtle shifts in transcription factor expression. J Exp Med 2002;195:F43–F47.

    Article  PubMed  CAS  Google Scholar 

  13. Nerlov C, Graf T. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev 1998;12:2403–2412.

    Article  PubMed  CAS  Google Scholar 

  14. Nerlov C, McNagny KM, Doderlein G, Kowenz-Leutz E, Graf T. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Genes Dev 1998;12:2413–2423.

    Article  PubMed  CAS  Google Scholar 

  15. Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, et al. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med 2002;195:1387–1395.

    Article  PubMed  CAS  Google Scholar 

  16. Hirasawa R, Shimizu R, Takahashi S, Osawa M, Takayanagi S, Kato Y, et al. Essential and instructive roles of GATA factors in eosinophil development. J Exp Med 2002;195:1379–1386.

    Article  PubMed  CAS  Google Scholar 

  17. Lopez AF, Begley CG, Williamson DJ, Warren DJ, Vadas MA, Sanderson CJ. Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells. J Exp Med 1986;163:1085–1099.

    Article  PubMed  CAS  Google Scholar 

  18. Rothenberg ME, Pomerantz JL, Owen WF, Avraham S, Soberman RJ, Austen KF, et al. Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. J Biol Chem 1988;263:13901–13908.

    PubMed  CAS  Google Scholar 

  19. Lopez AF, Sanderson CJ, Gamble JR, Campbell HD, Young IG, Vadas MA. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J Exp Med 1988;167:219–224.

    Article  PubMed  CAS  Google Scholar 

  20. Takatsu K, Takaki S, Hitoshi Y. Interleukin-5 and its receptor system: implications in the immune system and inflammation. Adv Immunol 1994;57:145–190.

    Article  PubMed  CAS  Google Scholar 

  21. Sanderson CJ. Interleukin-5, eosinophils, and disease. Blood 1992;79:3101–3109.

    PubMed  CAS  Google Scholar 

  22. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995;182:1169–1174.

    Article  PubMed  CAS  Google Scholar 

  23. Foster P, Hogan S, Ramsay A, Matthaei K, Young I. Interleukin-5 deficiency abolishes eosinophilia, airway hyperreactivity and lung damage in a mouse asthma model. J Exp Med 1996; 183:195–201.

    Article  PubMed  CAS  Google Scholar 

  24. Kopf M, Brombacher F, Hodgkin PD, Ramsay AJ, Milbourne EA, Dai WJ, et al. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 1996;4:15–24.

    Article  PubMed  CAS  Google Scholar 

  25. Dent LA, Strath M, Mellor AL, Sanderson CJ. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med 1990;172:1425–1431.

    Article  PubMed  CAS  Google Scholar 

  26. Tominaga A, Takaki S, Koyama N, Katoh S, Matsumoto R, Migita M, et al. Transgenic mice expressing a B cell growth and differentiation factor (interleukin 5) develop eosinophilia and autoantibody production. J Exp Med 1991;173:429–437.

    Article  PubMed  CAS  Google Scholar 

  27. Lee JJ, McGarry MP, Farmer SC, Denzler KL, Larson KA, Carrigan PE, et al. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med 1997;185:2143–2156.

    Article  PubMed  CAS  Google Scholar 

  28. Mishra A, Hogan SP, Brandt EB, Wagner N, Crossman MW, Foster PS, et al. Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking. J Biol Chem 2002;277:4406–4412.

    Article  PubMed  CAS  Google Scholar 

  29. Bochner BS, Schleimer RP. The role of adhesion molecules in human eosinophil and basophil recruitment. J Allergy Clin Immunol 1994;94:427–438.

    Article  PubMed  CAS  Google Scholar 

  30. Gouon-Evans V, Rothenberg ME, Pollard JW. Postnatal mammary gland development requires macrophages and eosinophils. Development (Camb) 2000;127:2269–2282.

    CAS  Google Scholar 

  31. Rothenberg ME, Mishra A, Brandt EB, Hogan SP. Gastrointestinal eosinophils in health and disease. Adv Immunol 2001;78:291–328.

    Article  PubMed  CAS  Google Scholar 

  32. Mishra A, Hogan SP, Lee JJ, Foster PS, Rothenberg ME. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest 1999;103:1719–1727.

    Article  PubMed  CAS  Google Scholar 

  33. Rothenberg ME, Owen WF Jr, Silberstein DS, Soberman RJ, Austen KF, Stevens RL. Eosinophils co-cultured with endothelial cells have increased survival and functional properties. Science 1987;237:645–647.

    Article  PubMed  CAS  Google Scholar 

  34. Sher A, Coffman RL, Hieny S, Cheever AW. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J Immunol 1990;145:3911–3916.

    PubMed  CAS  Google Scholar 

  35. Horie S, Okubo Y, Hossain M, Sato E, Nomura H, Koyama S, et al. Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis. Intern Med 1997;36:179–185.

    Article  PubMed  CAS  Google Scholar 

  36. Zimmermann N, Hershey GK, Foster PS, Rothenberg ME. Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol 2003;111:227–242.

    Article  PubMed  CAS  Google Scholar 

  37. Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004;304:1678–1682.

    Article  PubMed  CAS  Google Scholar 

  38. Rankin SM, Conroy DM, Williams TJ. Eotaxin and eosinophil recruitment: implications for human disease. Mol Med Today 2000;6:20–27.

    Article  PubMed  CAS  Google Scholar 

  39. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995;182:1169–1174.

    Article  PubMed  CAS  Google Scholar 

  40. Matthews AN, Friend DS, Zimmermann N, Sarafi MN, Luster AD, Pearlman E, et al. Eotaxin is required for the baseline level of tissue eosinophils. Proc Natl Acad Sci U S A 1998;95:6273–6278.

    Article  PubMed  CAS  Google Scholar 

  41. Hogan SP, Mishra A, Brandt EB, Royalty MP, Pope SM, Zimmermann N, et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol 2001;2:353–360.

    Article  PubMed  CAS  Google Scholar 

  42. Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 1994;179:881–887.

    Article  PubMed  CAS  Google Scholar 

  43. Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med 1995;181:1211–1216.

    Article  PubMed  CAS  Google Scholar 

  44. Garcia-Zepeda EA, Combadiere C, Rothenberg ME, Sarafi MN, Lavigne F, Hamid Q, et al. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and-3. J Immunol 1996;157:5613–5626.

    PubMed  CAS  Google Scholar 

  45. Rothenberg ME. Eotaxin. An essential mediator of eosinophil trafficking into mucosal tissues. Am J Respir Cell Mol Biol 1999;21:291–295.

    PubMed  CAS  Google Scholar 

  46. Mishra A, Rothenberg ME. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology 2003;125:1419–1427.

    Article  PubMed  CAS  Google Scholar 

  47. Gleich GJ, Adolphson CR. The eosinophilic leukocyte: structure and function. Adv Immunol 1986;39:177–253.

    Article  PubMed  CAS  Google Scholar 

  48. Slifman NR, Loegering DA, McKean DJ, Gleich GJ. Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein. J Immunol 1986;137:2913–2917.

    PubMed  CAS  Google Scholar 

  49. Hogan SP, Rothenberg ME, Forbes E Smart VE, Matthaei KI, Foster PS. Chemokines in eosinophil-associated gastrointestinal disorders. Curr Allergy Asthma Rep 2004;4:74–82.

    Article  PubMed  Google Scholar 

  50. Straumann A, Simon HU. The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract. Allergy 2004;59:15–25.

    Article  PubMed  CAS  Google Scholar 

  51. Kelly KJ. Eosinophilic gastroenteritis. J Pediatr Gastroenterol Nutr 2000;30:S28–S35.

    Article  PubMed  Google Scholar 

  52. Von Wattenwyl F, Zimmermann A, Netzer P. Synchronous first manifestation of an idiopathic gastroenteritis and bronchial asthma. Eur J Gastroenterol Hepatol 2001;13:721–725.

    Article  Google Scholar 

  53. Hogan SP, Mishra A, Brandt EB, Foster PS, Rothenberg ME. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. Proc Natl Acad Sci USA 2000;97:6681–6686.

    Article  PubMed  CAS  Google Scholar 

  54. Jaffe JS, James SP, Mullins GE, Braun-Elwert L, Lubensky I, Metcalfe DD. Evidence for an abnormal profile of interleukin-4 (IL-4), IL-5, and gamma-interferon (gamma-IFN) in peripheral blood T cells from patients with allergic eosinophilic gastroenteritis. J Clin Immunol 1994;14:299–309.

    Article  PubMed  CAS  Google Scholar 

  55. Beyer K, Castro R, Birnbaum A, Benkov K, Pittman N, Sampson HA. Human milk-specific mucosal lymphocytes of the gastrointestinal tract display a TH2 cytokine profile. J Allergy Clin Immunol 2002;109:707–713.

    Article  PubMed  CAS  Google Scholar 

  56. Khan S, Orenstein SR. Eosinophilic gastroenteritis: epidemiology, diagnosis and management. Paediatr Drugs 2002;4:563–570.

    PubMed  Google Scholar 

  57. Kim NI, Jo YJ, Song MH, Kim SH, Kim TH, Park, YS, et al. Clinical features of eosinophilic gastroenteritis (in Korean with English abstract). Korean J Gastroenterol 2004;44:217–223.

    PubMed  Google Scholar 

  58. Friesen CA, Kearns GL, Andre L, Neustrom M, Roberts CC, Abdel-Rahman SM. Clinical efficacy and pharmacokinetics of montelukast in dyspeptic children with duodenal eosinophilia. J Pediatr Gastroenterol Nutr 2004;38:343–351.

    Article  PubMed  Google Scholar 

  59. Chen MJ, Chu CH, Lin SC, Shih SC, Wang TE. Eosinophilic gastroenteritis: clinical experience with 15 patients. World J Gastroenterol 2003;9:2813–2816.

    PubMed  Google Scholar 

  60. Tursi A, Rella G, Inchingolo CD, Maiorano M. Gastric outlet obstruction due to gastroduodenal eosinophilic gastroenteritis. Endoscopy 2007;39(suppl 1):E184.

    Article  PubMed  Google Scholar 

  61. Whitaker IS, Gulati A, McDaid JO, Bugajska-Carr U, Arends MJ. Eosinophilic gastroenteritis presenting as obstructive jaundice. Eur J Gastroenterol Hepatol 2004;16:407–409.

    Article  PubMed  CAS  Google Scholar 

  62. Polyak S, Smith TA, Mertz H. Eosinophilic gastroenteritis causing pancreatitis and pancreaticobiliary ductal dilation. Dig Dis Sci 2002;47:1091–1095.

    Article  PubMed  CAS  Google Scholar 

  63. Tran D, Salloum L, Tshibaka C, Moser R. Eosinophilic gastroenteritis mimicking acute appendicitis. Am Surg 2000;66:990–992.

    PubMed  CAS  Google Scholar 

  64. Yun MY, Cho YU, Park IS, Choi SK, Kim SJ, Shin SH, et al. Eosinophilic gastroenteritis presenting as small bowel obstruction: a case report and review of the literature. World J Gastroenterol 2007;13:1758–1760.

    PubMed  Google Scholar 

  65. Christopher V, Thompson MH, Hughes S. Eosinophilic gastroenteritis mimicking pancreatic cancer. Postgrad Med J 2000;78:498–499.

    Article  Google Scholar 

  66. Gregg JA, Utz DC. Eosinophilic cystitis associated with eosinophilic gastroenteritis. Mayo Clin Proc 1974;49185–49187.

  67. Zhou HB, Chen JM, Du Q. Eosinophilic gastroenteritis with ascites and hepatic dysfunction. World J Gastroenterol 2007;13:1303–1305.

    Article  PubMed  Google Scholar 

  68. Robert F, Omura E, Durant JR. Mucosal eosinophilic gastroenteritis with systemic involvement. Am J Med 1977;62:139–143.

    Article  PubMed  CAS  Google Scholar 

  69. Méndez-Sánchez N, Chávez-Tapia NC, Vazquez-Elizondo G, Uribe M. Eosinophilic gastroenteritis: a review. Dig Dis Sci 2007;52:2904–2911.

    Article  PubMed  Google Scholar 

  70. Khan S. Eosinophilic gastroenteritis. Best Pract Res Clin Gastroenterol 2005;19:177–198.

    Article  PubMed  Google Scholar 

  71. Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007;133:1342–1363.

    Article  PubMed  CAS  Google Scholar 

  72. Khan S, Orenstein SR. Eosinophilic gastroenteritis masquerading as pyloric stenosis. Clin Pediatr (Phila) 2000;39:55–57.

    CAS  Google Scholar 

  73. Teele RL, Katz AJ, Goldman H, Kettell RM. Radiographic features of eosinophilic gastroenteritis (allergic gastroenteropathy) of childhood. Am J Roentgenol 1979;132:575–580.

    CAS  Google Scholar 

  74. Horton KM, Corl FM, Fishman EK. CT of nonneoplastic diseases of the small bowel: spectrum of disease. J Comput Assist Tomogr 1999;23:417–428.

    Article  PubMed  CAS  Google Scholar 

  75. Imai E, Kaminaga T, Kawasugi K, Yokokawa T, Furui S. The usefulness of 99 mTc-hexamethylpropyleneamineoxime white blood cell scintigraphy in a patient with eosinophilic gastroenteritis. Ann Nucl Med 2003;17:601–603.

    PubMed  Google Scholar 

  76. Katsumi N, Yamaguchi Y, Yamato T, Morozumi K, Abe T, Ishida H, et al. Multiple ulcerative lesions of the stomach: a rare case of eosinophilic gastroenteritis. Gastrointest Endosc 2002;56:762–764.

    Article  PubMed  Google Scholar 

  77. Lee CM, Changchien CS, Chen PC, Lin DY, Sheen IS, Wang CS, et al. Eosinophilic gastroenteritis: 10 years experience. Am J Gastroenterol 1993;88:70–74.

    PubMed  CAS  Google Scholar 

  78. Lee M, Hodges WG, Huggins TL, Lee EL. Eosinophilic gastroenteritis. South Med J 1996;89:189–194.

    PubMed  CAS  Google Scholar 

  79. Ahmad M, Soetikno RM, Ahmed A. The differential diagnosis of eosinophilic esophagitis. J Clin Gastroenterol 2000;30:242–244.

    Article  PubMed  CAS  Google Scholar 

  80. Alamo Martinez JM, Ibanez Delgado F, Galindo Galindo A, Bernnal Bellido C, Duren Ferreras I, Suarez Artacho G, et al. Intestinal obstruction by eosinophilic jejunitis. Rev Esp Enferm Dig 2004;96:1419–1427.

    Google Scholar 

  81. Walker NI, Croese J, Clouston AD, Parry M, Loukas A, Prociv C. Eosinophilic enteritis in northeastern Australia. Pathology, association with Ancylostoma caninum, and implications. Am J Surg Pathol 1995;19:328–337.

    PubMed  CAS  Google Scholar 

  82. Macedo T, MacCarty RL. Eosinophilic ileocolitis secondary to Enterobius vermicularis: case report. Abdom Imaging 2000;25:530–532.

    Article  PubMed  CAS  Google Scholar 

  83. Ashby BS, Appleton PJ, Dawson I. Eosinophilic granuloma of gastrointestinal tract caused by herring parasite Eustoma rotundatum. Br Med J 1964;5391:1141–1145.

    Google Scholar 

  84. Esteve C, Resano A, Diaz-Tejeiro P, Fernandez-Benitez M. Eosinophilic gastritis due to Anisakis: a case report. Allergol Immunopathol (Madr) 2000;28:21–23.

    CAS  Google Scholar 

  85. Repiso Ortega A, Alcantara Torres M, Gonzalez de Frutos C, de Artaza Varasa T, Rodriguez Merlo R, Valle Munoz J, et al. Gastrointestinal anisakiasis. Study of a series of 25 patients (in Spanish with English abstract). Gastroenterol Hepatol 2003;26:341–346.

    Article  PubMed  CAS  Google Scholar 

  86. Takeyama Y, Kamimura S, Suzumiya J, Oh K, Okumura M, Akahane H, et al. Case report: eosinophilic colitis with high antibody titre against Ascaris suum. J Gastroenterol Hepatol 1997;12:204–206.

    Article  PubMed  CAS  Google Scholar 

  87. Hong ST, Lim HS, Kim DH, Kim SJ. A case of gastroenteritis associated with gastric trichuriasis. J Korean Med Sci 2003;18:429–432.

    PubMed  Google Scholar 

  88. Bogers J, Moreels T, De Man J, Vrolix G, Jacobs W, Pelckmans P, et al. Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine. Neurogastroenterol Motil 2000;12:431–440.

    Article  PubMed  CAS  Google Scholar 

  89. Van Laethem JL, Jacobs F, Braude P, Van Gossum A, Deviere J. Toxocara canis infection presenting as eosinophilic ascites and gastroenteritis. Dig Dis Sci 1994;39:1370–1372.

    Article  PubMed  Google Scholar 

  90. Corsetti M, Basilisco G, Pometta R, Allocca M, Conte D. Mistaken diagnosis of eosinophilic colitis. Ital J Gastroenterol Hepatol 1999;31:607–609.

    PubMed  CAS  Google Scholar 

  91. Saba R, Korkmaz M, Inan D, Mamikoglu L, Turhan O, Gunseren F, et al. Human fascioliasis. Clin Microbiol Infect 2004;10:385–387.

    Article  PubMed  CAS  Google Scholar 

  92. Levy AM, Gleich GJ, Sandborn WJ, Tremaine WJ, Steiner BL, Phillips SF. Increased eosinophil granule proteins in gut lavage fluid from patients with inflammatory bowel disease. Mayo Clin Proc 1997;72:117–123.

    PubMed  CAS  Google Scholar 

  93. Chusid MJ, Dale DC, West BC, Wolff SM. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltim) 1975;54:1–27.

    Article  CAS  Google Scholar 

  94. Weller PF, Bubley GJ. The idiopathic hypereosinophilic syndrome. Blood 1994,83:2759–2779.

    PubMed  CAS  Google Scholar 

  95. Solans R, Bosch JA, Perez-Bocanegra C, Selva A, Huguet P, Alijotas J, et al. Churg-Strauss syndrome: outcome and longterm follow-up of 32 patients. Rheumatology (Oxf) 2001;40:763–771.

    Article  CAS  Google Scholar 

  96. Blackshaw AJ, Levison DA. Eosinophilic infiltrates of the gastrointestinal tract. J Clin Pathol 1986;39:1–7.

    Article  PubMed  CAS  Google Scholar 

  97. DeSchryver-Kecskemeti K, Clouse RE. A previously unrecognized subgroup of ‘eosinophilic gastroenteritis.’ Association with connective tissue diseases. Am J Surg Pathol 1 1984;8:171–180.

    Article  CAS  Google Scholar 

  98. Clouse RE, Alpers DH, Hockenbery DM, DeSchryver-Kecskemeti K. Pericrypt eosinophilic enterocolitis and chronic diarrhea. Gastroenterology 1992;103:168–176.

    PubMed  CAS  Google Scholar 

  99. Michet CJ Jr, Rakela J, Luthra HS. Auranofin-associated colitis and eosinophilia. Mayo Clin Proc 1987;62:142–144.

    PubMed  Google Scholar 

  100. Riedel RR, Schmitt A, de Jonge JP, Hartmann A. Gastrointestinal type 1 hypersensitivity to azathioprine. Klin Wochenschr 1990;68:50–52.

    Article  PubMed  CAS  Google Scholar 

  101. Lee JY, Medellin MV, Tumpkin C. Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis. South Med J 2000;93:807–808.

    PubMed  CAS  Google Scholar 

  102. Shakeer VK, Devi SR, Chettupuzha AP, Mustafa CP, Sandesh K, Kumar SK, et al. Carbamazepine-induced eosinophilic enteritis. Indian J Gastroenterol 2002;21:114–115.

    PubMed  CAS  Google Scholar 

  103. Ravi S, Holubka J, Veneri R, Youn K, Khatib R. Clofazimine-induced eosinophilic gastroenteritis in AIDS. Am J Gastroenterol 1993;88:612–613.

    PubMed  CAS  Google Scholar 

  104. Hogan SP, Rothenberg ME. Review article: The eosinophil as a therapeutic target in gastrointestinal disease. Aliment Pharmacol Ther 2004;20:1231–1240.

    Article  PubMed  CAS  Google Scholar 

  105. Justinich C, Katz A, Gurbindo C, Lepage G, Chad Z, Bouthillier L, et al. Elemental diet improves steroid-dependent eosinophilic gastroenteritis and reverses growth failure. J Pediatr Gastroenterol Nutr 1996;23:81–85.

    Article  PubMed  CAS  Google Scholar 

  106. Chehade M, Sicherer SH, Magid MS, Rosenberg HK, Morotti RA. Multiple exudative ulcers and pseudopolyps in allergic eosinophilic gastroenteritis that responded to dietary therapy. J Pediatr Gastroenterol Nutr 2007;45:354–357.

    PubMed  Google Scholar 

  107. Tan AC, Kruimel JW, Naber TH. Eosinophilic gastroenteritis treated with non-enteric-coated budesonide tablets. Eur J Gastroenterol Hepatol 2001;13:425–427.

    Article  PubMed  CAS  Google Scholar 

  108. Perez-Millan A, Martin-Lorente JL, Lopez-Morante A, Yuguero L, Saez-Royuela F. Subserosal eosinophilic gastroenteritis treated efficaciously with sodium cromoglycate. Dig Dis Sci 1997;42:342–344.

    Article  PubMed  CAS  Google Scholar 

  109. Katsinelos P, Pilpilidis I, Xiarchos P, Christodoulou K, Papagiannis A, Tsolkas P, et al. Oral administration of ketotifen in a patient with eosinophilic colitis and severe osteoporosis. Am J Gastroenterol 2002;97:1072–1074.

    Article  PubMed  Google Scholar 

  110. Bolukbas FF, Bolukbas C, Uzunkoy A, Baba F, Horoz M, Ozturk E. A dramatic response to ketotifen in a case of eosinophilic gastroenteritis mimicking abdominal emergency. Dig Dis Sci 2004;49:1782–1785.

    Article  PubMed  Google Scholar 

  111. Schwartz DA, Pardi DS, Murray JA. Use of montelukast as steroid-sparing agent for recurrent eosinophilic gastroenteritis. Dig Dis Sci 2001;46:1787–1790.

    Article  PubMed  CAS  Google Scholar 

  112. Quack I, Sellin L, Buchner NJ, Theegarten D, Rump LC, Henning BF. Eosinophilic gastroenteritis in a young girl: longterm remission under Montelukast. BMC Gastroenterol 2005;5:24–28.

    Article  PubMed  Google Scholar 

  113. Daikh BE, Ryan CK, Schwartz RH. Montelukast reduces peripheral blood eosinophilia but not tissue eosinophilia or symptoms in a patient with eosinophilic gastroenteritis and esophageal stricture. Ann Allergy Asthma Immunol 2003;90:23–27.

    Article  PubMed  CAS  Google Scholar 

  114. Suzuki J, Kawasaki Y, Nozawa R, Isome M, Suzuki S, Takahashi A, et al. Oral disodium cromoglycate and ketotifen for a patient with eosinophilic gastroenteritis, food allergy and protein-losing enteropathy. Asian Pac J Allergy Immunol 2003;21:193–197.

    PubMed  Google Scholar 

  115. Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DK, et al. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol 2004;113:115–119.

    Article  PubMed  CAS  Google Scholar 

  116. Bochner BS. Verdict in the case of therapies versus eosinophils: the jury is still out. J Allergy Clin Immunol 2004;113:3–9.

    Article  PubMed  CAS  Google Scholar 

  117. Landres RT, Kuster GG, Strum WB. Eosinophilic esophagitis in a patient with vigorous achalasia. Gastroenterology 1987;74:1298–1301.

    Google Scholar 

  118. Chang F, Anderson S. Clinical and pathological features of eosinophilic oesophagitis: a review. Pathology 2008;40:3–8.

    Article  PubMed  Google Scholar 

  119. Furuta GT, Straumann A. Review article: the pathogenesis and management of eosinophilic oesophagitis. Aliment Pharmacol Ther 2006;24:173–182

    Article  PubMed  CAS  Google Scholar 

  120. Katzka DA. Eosinophilic esophagitis. Curr Opin Gastroenterol 2006;22:429–432.

    Article  PubMed  Google Scholar 

  121. Brown-Whitehorn T, Liacouras CA. Eosinophilic esophagitis. Curr Opin Pediatr 2007;19:575–580.

    Article  PubMed  Google Scholar 

  122. Pasha SF, DiBaise JK, Kim HJ, De Petris G, Crowell MD, Fleischer DE, et al. Patient characteristics, clinical, endoscopic, and histologic findings in adult eosinophilic esophagitis: a case series and systematic review of the medical literature. Dis Esophagus 2007;20:311–319.

    Article  PubMed  CAS  Google Scholar 

  123. Straumann A, Simon HU. Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Immunol 2005;115:418–419.

    Article  PubMed  Google Scholar 

  124. Cherian S, Smith NM, Forbes DA. Rapidly increasing prevalence of eosinophilic oesophagitis in Western Australia. Arch Dis Childhood 2006;91:1000–1004.

    Article  CAS  Google Scholar 

  125. Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic esophagitis. N Engl J Med 2004;351:940–941.

    Article  PubMed  CAS  Google Scholar 

  126. Guajardo J, Plotnick L, Fende J, Collins MH, Putnam PE, Rothenberg ME. Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry. J Pediatr 2002;141:576–581.

    Article  PubMed  Google Scholar 

  127. Liacouras CA, Spergel JM, Ruchelli E, Verma R, Mascarenhas M, Semeao E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005;3:1198–1206.

    Article  PubMed  Google Scholar 

  128. Kerlin P, Jones D, Remedios M, Campbell C. Prevalence of eosinophilic esophagitis in adults with food bolus obstruction of the esophagus. J Clin Gastroenterol 2007;41:356–361.

    Article  PubMed  Google Scholar 

  129. Zink DA, Amin M, Gebara S, Desai TK. Familial dysphagia and eosinophilia. Gastrointest Endosc 2007;65:330–334.

    Article  PubMed  Google Scholar 

  130. Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology 2003;125:1660–1669.

    Article  PubMed  Google Scholar 

  131. Lucendo AJ, Navarro M, Comas C, Pascual JM, Burgos E, Santamaría L, et al. Immunophenotypic characterization and quantification of the epithelial inflammatory infiltrate in eosinophilic esophagitis through stereology: an analysis of the cellular mechanisms of the disease and the immunologic capacity of the esophagus. Am J Surg Pathol 2007;31:598–606.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University Health Network/Toronto Medical Laboratories, University of Toronto, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada

    Hwa Eun Oh & Runjan Chetty

  2. Department of Pathology, Myongji Hospital, Kwandong University, College of Medicine, Goyang, Korea

    Hwa Eun Oh

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  1. Hwa Eun Oh
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  2. Runjan Chetty
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Oh, H.E., Chetty, R. Eosinophilic gastroenteritis: a review. J Gastroenterol 43, 741–750 (2008). https://doi.org/10.1007/s00535-008-2230-5

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