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Evaluation of the effects of methanol leaf extract of Palisota hirsuta on the biochemical and hematological parameters of rats

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Abstract

The effects of 28-day oral administration of the methanol leaf extract of Palisota hirsuta (MLEPH) on biochemical, hematological parameters, and relative organ weights (ROWs) in albino rats were investigated. There were no significant (p > 0.05) variations in the ROW of the heart, kidney, spleen, and liver on days 14 and 28 in all the rats given the different doses of MLEPH. The hematology showed that there were no significant (p > 0.05) alterations of the packed cell volume (PCV), hemoglobin concentration, RBC count, total white blood cell (tWBC), and differential WBC counts by MLEPH at 20, 40, 80, and 160 mg/kg when compared with control. The serum biochemistry also revealed no significant (p > 0.05) variations in the serum activities of aspartate aminotransferase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP), total protein, total bilirubin, and creatinine when the groups that received the extract at the different doses were compared with the control. Therefore, MLEPH did not cause significant toxicity after 28 days of oral administration.

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Acknowledgments

We wish to appreciate Mr. A.O Ozioko for the identification of the plant material. We are also grateful to the management of Science Education Post Basics (STEB-B) project UNN, for providing some materials required for this work.

Conflict of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of this paper.

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Authors and Affiliations

  1. Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria

    A. O. Anaga

  2. Department of Veterinary Surgery, University of Nigeria, Nsukka, Enugu State, Nigeria

    C. Unamba-Oparah

  3. Department of Veterinary Pathology, University of Nigeria, Nsukka, Enugu State, Nigeria

    Ihemdirim Chukwuma Unamba-Oparah

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  1. Ihemdirim Chukwuma Unamba-Oparah
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  2. C. Unamba-Oparah
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  3. A. O. Anaga
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Correspondence to Ihemdirim Chukwuma Unamba-Oparah.

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Unamba-Oparah, I.C., Unamba-Oparah, C. & Anaga, A.O. Evaluation of the effects of methanol leaf extract of Palisota hirsuta on the biochemical and hematological parameters of rats. Comp Clin Pathol 25, 271–277 (2016). https://doi.org/10.1007/s00580-015-2177-x

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  • DOI: https://doi.org/10.1007/s00580-015-2177-x

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