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Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis

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Abstract

Purpose

Complications of adult spinal deformity surgery are problematic in osteoporotic individuals. We compared outcomes between Japanese patients treated perioperatively with teriparatide vs. low-dose bisphosphonates.

Methods

Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion. Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age. Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.

Results

Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.

Conclusions

Perioperative administration of teriparatide is more effective than that of low-dose bisphosphonates in preventing complications and maintaining fusion rates in osteoporotic Japanese females with spinal deformities undergoing surgery.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Shoji Seki, Yoshiharu Kawaguchi, Taketoshi Yasuda, Kayo Suzuki, Kenta Watanabe, Hiroto Makino, Masahiko Kanamori & Tomoatsu Kimura

  2. Department of Orthopaedic Surgery, Toyama Rosai Hospital, Toyama, 937-0042, Japan

    Norikazu Hirano

  3. Department of Orthopaedic Surgery, Takaoka City Hospital, Toyama, 933-8550, Japan

    Masato Nakano

Authors
  1. Shoji Seki
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  2. Norikazu Hirano
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  3. Yoshiharu Kawaguchi
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  4. Masato Nakano
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  5. Taketoshi Yasuda
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  6. Kayo Suzuki
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  7. Kenta Watanabe
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  8. Hiroto Makino
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  9. Masahiko Kanamori
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  10. Tomoatsu Kimura
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Corresponding author

Correspondence to Shoji Seki.

Ethics declarations

All study participants provided informed consent, and the study methods were conducted in accordance with the Declaration of Helsinki.

Conflict of interest

The authors declare that they have no conflict of interest concerning this article. No funds were received in support of this work.

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Seki, S., Hirano, N., Kawaguchi, Y. et al. Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis. Eur Spine J 26, 2121–2127 (2017). https://doi.org/10.1007/s00586-017-4959-0

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  • DOI: https://doi.org/10.1007/s00586-017-4959-0

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