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Human adipose-derived stem cells: Potential clinical applications in surgery

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Abstract

Regenerative medicine is emerging as a rapidly evolving field of research and therapeutics. Stem cells hold great promise for future translational research and clinical applications in many fields. Much research has focused on mesenchymal stem cells isolated from bone marrow in vitro and in vivo; however, bone marrow procurement causes considerable discomfort to the patient and yields a relatively small number of harvested cells. By contrast, adipose tissue represents an abundant and easily accessible source of adult stem cells, termed adipose-derived stem cells (ADSCs), with the ability to equally differentiate along multiple lineage pathways. These stem cells have angiogenic properties, possibly because of their secretion of cytokines. They may also play a role in healing acute and chronic tissue damage. Subsequently, they have a wide range of potential clinical implications. This article reviews the potential preclinical and clinical applications of mesenchymal stem cells, especially ADSCs, in surgery.

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Authors and Affiliations

  1. Cancer Clinical Cooperation Center, Tokushima University Hospital, 3-18-15 kuramoto-cho, Tokushima, 770-8503, Japan

    Tohru Utsunomiya

  2. Department of Surgery, The University of Tokushima, Tokushima, Japan

    Tohru Utsunomiya, Mitsuo Shimada, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Hiroki Mori, Jun Hanaoka, Shuichi Iwahashi & Yu Saito

  3. Cytori Therapeutics, Inc., San Diego, CA, USA

    Hideki Iwaguro

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  1. Tohru Utsunomiya
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Utsunomiya, T., Shimada, M., Imura, S. et al. Human adipose-derived stem cells: Potential clinical applications in surgery. Surg Today 41, 18–23 (2011). https://doi.org/10.1007/s00595-010-4415-9

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  • DOI: https://doi.org/10.1007/s00595-010-4415-9

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