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Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer

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Abstract

Purpose

The aim of this study was to determine the utility of the peritoneal lavage cytology findings in predicting the clinical outcomes of resectable left-sided pancreatic cancer.

Methods

Peritoneal lavage samples were collected from 39 consecutive patients who underwent surgery for left-sided pancreatic cancer between January 2000 and December 2010. We analyzed the correlations between the peritoneal lavage cytology findings and the clinical outcomes.

Results

Five patients (12.8 %) had malignant cells in the cytology samples (positive cytology). This occurred more frequently in patients with vascular invasion (P = 0.008). Positive cytology was significantly associated with lower overall (P = 0.0007) and recurrent-free (P < 0.0001) survival rates. Positive cytology was an independent prognostic factor for recurrence (P = 0.022); it was closely associated with local recurrence, peritoneal recurrence and distant metastasis.

Conclusion

Surgeons should carefully consider the intraoperative diagnosis of peritoneal lavage cytology in patients with resectable left-sided pancreatic cancers, because patients with positive cytology are likely to experience recurrence.

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Conflict of interest

Yoshifumi Iwagami and co-authors have no conflicts of interest to declare in association with this study.

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Authors and Affiliations

  1. Department of Surgery, Graduate School of Medicine, Osaka University, Yamadaoka 2-2 (E2), Suita, Osaka, 565-0871, Japan

    Yoshifumi Iwagami, Hidetoshi Eguchi, Hiroshi Wada, Yoshito Tomimaru, Naoki Hama, Koichi Kawamoto, Shogo Kobayashi, Masaki Mori, Yuichiro Doki & Hiroaki Nagano

Authors
  1. Yoshifumi Iwagami
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  2. Hidetoshi Eguchi
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  3. Hiroshi Wada
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  4. Yoshito Tomimaru
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  5. Naoki Hama
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  6. Koichi Kawamoto
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  7. Shogo Kobayashi
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  8. Masaki Mori
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  9. Yuichiro Doki
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  10. Hiroaki Nagano
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Correspondence to Hiroaki Nagano.

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Iwagami, Y., Eguchi, H., Wada, H. et al. Implications of peritoneal lavage cytology in resectable left-sided pancreatic cancer. Surg Today 45, 444–450 (2015). https://doi.org/10.1007/s00595-014-0964-7

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  • DOI: https://doi.org/10.1007/s00595-014-0964-7

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