Summary
The Chromogranin B (CHGB) gene has been proposed as a candidate gene for predisposition to schizophrenia due to its location on the genome, the evidence of genetic studies, and its functional role in schizophrenia. To investigate its association with schizophrenia using case-control analysis, we genotyped eight single nucleotide polymorphisms (SNPs) and performed transmission disequilibrium tests (TDT) using 192 Han Chinese trios. The G allele of IVS4 + 808A > G showed a trend of over-transmission from heterozygous parents to affected offspring (P = 0.06), although no significant over-transmission was found for individual markers. Furthermore, a significant transmission was observed for the common haplotype G-G-A-G-C (P = 0.0018). Overall, our results suggest that at least one locus in or close to the CHGB gene confers risk of the disorder and strengthen the evidence that CHGB is a promising susceptibility gene for schizophrenia in Chinese population.
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References
JA Badner LR Goldin (1999) ArticleTitleMeta-analysis of linkage studies Genet Epidemiol 1 IssueIDSuppl 1 S485–S490
S Duan J Du Y Xu Q Xing H Wang S Wu Q Chen X Li J Shen G Feng L He (2006) ArticleTitleFailure to find association between TRAR4 and schizophrenia in the Chinese Han population J Neural Transm 113 381–385 Occurrence Handle16075187 Occurrence Handle10.1007/s00702-005-0335-z Occurrence Handle1:CAS:528:DC%2BD28XhtVajtLw%3D
F Dudbridge (2003) ArticleTitlePedigree disequilibrium tests for multilocus haplotypes Genet Epidemiol 25 115–121 Occurrence Handle12916020 Occurrence Handle10.1002/gepi.10252
M Flaum X Amador J Gorman HS Bracha W Edell T McGlashan A Pandurangi KS Kendler D Robinson J Lieberman A Ontiveros M Tohen P McGorry G Tyrrell S Arndt NC Andreasen (1997) DSM-IV field trial for schizophrenia and other psychotic disorders DSM-IV Sourcebook NumberInSeries4 American Psychiatric Association Washington, DC 687–713
WB Huttner HH Gerdes P Rosa (1991) ArticleTitleThe granin (chromogranin/secretogranin) family Trends Biochem Sci 16 27–30 Occurrence Handle2053134 Occurrence Handle10.1016/0968-0004(91)90012-K Occurrence Handle1:CAS:528:DyaK3MXisVartbw%3D
Y Iijima T Inada T Ohtsuki H Senoo M Nakatani T Arinami (2004) ArticleTitleAssociation between chromogranin b gene polymorphisms and schizophrenia in the Japanese population Biol Psychiatry 56 10–17 Occurrence Handle15219467 Occurrence Handle10.1016/j.biopsych.2004.03.012 Occurrence Handle1:CAS:528:DC%2BD2cXlt1amsrc%3D
Y Kitao T Inada T Arinami C Hirotsu S Aoki Y Iijima T Yamauchi G Yagi (2000) ArticleTitleA contribution to genome-wide association studies: search for susceptibility loci for schizophrenia using DNA microsatellite markers on chromosomes 19, 20, 21 and 22 Psychiatr Genet 10 139–143 Occurrence Handle11204350 Occurrence Handle1:STN:280:DC%2BD3M3gt1GmsA%3D%3D Occurrence Handle10.1097/00041444-200010030-00006
S Kroesen J Marksteiner B Leitner R Hogue-Angeletti R Fischer-Colbrie H Winkler (1996) ArticleTitleRat brain: distribution of immunoreactivity of PE-11, a peptide derived from chromogranin B Eur J Neurosci 8 2679–2689 Occurrence Handle8996818 Occurrence Handle10.1111/j.1460-9568.1996.tb01563.x Occurrence Handle1:STN:280:ByiC2M%2FgsVE%3D
M Landen B Grenfeldt P Davidsson M Stridsberg B Regland CG Gottfries K Blennow (1999) ArticleTitleReduction of chromogranin A and B but not C in the cerebrospinal fluid in subjects with schizophrenia Eur Neuropsychopharmacol 9 311–315 Occurrence Handle10422891 Occurrence Handle10.1016/S0924-977X(98)00042-X Occurrence Handle1:STN:280:DyaK1MzkvFOmtg%3D%3D
DF Levinson CM Lewis LH Wise (2002) ArticleTitleMeta-analysis of genome scans for schizophrenia Am J Med Genet 114 700–701
CM Lewis DF Levinson LH Wise LE DeLisi RE Straub I Hovatta NM Williams SG Schwab AE Pulver SV Faraone LM Brzustowicz CA Kaufmann DL Garver HM Gurling E Lindholm H Coon HW Moises W Byerley SH Shaw A Mesen R Sherrington FA O’Neill D Walsh KS Kendler J Ekelund T Paunio J Lonnqvist L Peltonen MC O’Donovan MJ Owen DB Wildenauer W Maier G Nestadt JL Blouin SE Antonarakis BJ Mowry JM Silverman RR Crowe CR Cloninger MT Tsuang D Malaspina JM Harkavy-Friedman DM Svrakic AS Bassett J Holcomb G Kalsi A McQuillin J Brynjolfson T Sigmundsson H Petursson E Jazin T Zoega T Helgason (2003) ArticleTitleGenome scan meta-analysis of schizophrenia and bipolar disorder, part II, Schizophrenia Am J Hum Genet 73 34–48 Occurrence Handle12802786 Occurrence Handle10.1086/376549 Occurrence Handle1:CAS:528:DC%2BD3sXlsVOitL8%3D
J Marksteiner R Bauer WA Kaufmann E Weiss U Barnas H Maier (1999) ArticleTitlePE-11, a peptide derived from chromogranin B, in the human brain Neuroscience 91 1155–1170 Occurrence Handle10391491 Occurrence Handle10.1016/S0306-4522(98)00676-9 Occurrence Handle1:CAS:528:DyaK1MXjtFChsbc%3D
N Takahashi R Ishihara S Saito N Maemo N Aoyama X Ji H Miura M Ikeda N Iwata T Suzuki T Kitajima Y Yamanouchi Y Kinoshita N Ozaki T Inada (2006) ArticleTitleAssociation between chromogranin A gene polymorphism and schizophrenia in the Japanese population Schizophr Res 83 179–183 Occurrence Handle16504480 Occurrence Handle10.1016/j.schres.2005.12.854
QH Xing SN Wu ZG Lin HF Li JD Yang GY Feng MT Wang WW Yang L He (2003) ArticleTitleAssociation analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene in schizophrenia Schizophr Res 65 9–14 Occurrence Handle14623368 Occurrence Handle10.1016/S0920-9964(03)00064-1
B Zhang Z Tan C Zhang Y Shi Z Lin N Gu G Feng L He (2002) ArticleTitlePolymorphisms of chromogranin B gene associated with schizophrenia in Chinese Han population Neurosci Lett 323 229–233 Occurrence Handle11959426 Occurrence Handle10.1016/S0304-3940(02)00145-3 Occurrence Handle1:CAS:528:DC%2BD38XivVSnsrk%3D
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Wu, S., Ma, J., Xing, Q. et al. Further evidence that the chromogranin B gene confers predisposition to schizophrenia: a family-based association study in Chinese. J Neural Transm 114, 641–644 (2007). https://doi.org/10.1007/s00702-006-0600-9
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DOI: https://doi.org/10.1007/s00702-006-0600-9