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Amantadine does not have antiviral activity against Borna disease virus

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Summary

We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 μM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.

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Authors and Affiliations

  1. Division of Virology, Department of Neuropharmacology,The Scripps Research Institute, La Jolla, California U.S.A., USA

    B. Cubitt & J. JC. de la Torre

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  1. B. Cubitt
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  2. J. JC. de la Torre
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Received May 20, 1997 Accepted June 19, 1997

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Cubitt, B., de la Torre, J.J. Amantadine does not have antiviral activity against Borna disease virus. Arch. Virol. 142, 2035–2042 (1997). https://doi.org/10.1007/s007050050220

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  • DOI: https://doi.org/10.1007/s007050050220

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