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Serum calcium and phosphorus concentrations and the outcome of calciphylaxis treatment with sodium thiosulfate

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Abstract

Calciphylaxis is severe condition with 45–55 % mortality occurring in chronic dialysis patients. Sporadically, the disease may develop in the patients with normal renal function, for example, in the presence of chronic renal inflammation. Sodium thiosulfate (STS) therapy is a treatment modality of calciphylaxis, but mechanism of its action is unknown. We report four cases of calciphylaxis treated with STS, illustrating that its therapeutic effect is not associated with decreased serum calcium or phosphorus concentration. Therapy with intravenous STS was safe and led to subjective improvement, due to pain reduction, and lesions healing in three of four patients. In one patient, complications of diabetes and other co-morbidities led to unfavorable outcome. STS can be considered promising drug in the treatment of calciphylaxis.

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References

  1. Musso CG, Enz P, Vidal F, Gelman R, Lizarraga A, Di Giuseppe L, Kowalczuk A, Garfi L, Galimberti R, Algranati L (2009) Saudi J Kidney Dis Transpl 20:1065

    Google Scholar 

  2. Brandenburg VM, Cozzolino M, Ketteler M (2011) J Nephrol 24:142

    Article  Google Scholar 

  3. Weenig RH (2008) J Am Acad Dermatol 58:458

    Article  Google Scholar 

  4. Nigwekar SU, Kroshinsky D, Nazarian RM, Goverman J, Malhotra R, Jackson VA, Kamdar MM, Steele DJ, Thadhani RI (2015) Am J Kidney Dis 66:133

    Article  Google Scholar 

  5. Salmhofer H, Franzen M, Hitzl W, Koller J, Kreymann B, Fend F, Hauser-Kronberger C, Heemann U, Berr F, Schmaderer C (2013) Kidney Blood Press Res 37:346

    Article  CAS  Google Scholar 

  6. Zitt E, König M, Vychytil A, Auinger M, Wallner M, Lingenhel G, Schilcher G, Rudnicki M, Salmhofer H, Lhotta K (2013) Nephrol Dial Transpl 28:1232

    Article  CAS  Google Scholar 

  7. Zakharov S, Pelclova D, Navratil T, Belacek J, Kurcova I, Komzak O, Salek T, Latta J, Turek R, Bocek R, Kucera C, Hubacek JA, Fenclova Z, Petrik V, Cermak M, Hovda KE (2014) Kidney Int 86:199

    Article  CAS  Google Scholar 

  8. Guldbakke KK, Khachemoune A (2007) Int J Dermatol 46:231

    Article  CAS  Google Scholar 

  9. Daudén E, Oñate MJ (2008) Dermatol Clin 26:557

    Article  Google Scholar 

  10. Rees JK, Coles GA (1969) Br Med J 2:670

    Article  CAS  Google Scholar 

  11. Selye H, Gentile G, Prioreschi P (1961) Science 134:1876

    Article  CAS  Google Scholar 

  12. Ketteler M, Biggar HP, Brandenburg VM, Schlieper G, Westenfeld R, Floege J (2007) Dtsch Arztebl 104:3481

    Google Scholar 

  13. Lipsker D, Chosidow O, Martinez F, Challier E, Francès C (1997) Arch Dermatol 133:798

    Article  CAS  Google Scholar 

  14. Russell R, Brookshire MA, Zekonis M, Moe SM (2002) Clin Nephrol 58:238

    Article  CAS  Google Scholar 

  15. Alikadic N, Kovac D, Krasna M, Lindic J, Sabovic M, Tomazic J, Jeras M, Smrke D (2009) Clin Transpl 23:968

    Article  Google Scholar 

  16. Cicone JS, Petronis JB, Embert CD, Spector DA (2004) Am J Kidney Dis 43:1104

    Article  Google Scholar 

  17. Zakharov S, Vaneckova M, Seidl Z, Diblik P, Kuthan P, Urban P, Navratil T, Pelclova D (2015) Basic Clin Pharmacol Toxicol 117:209

    Article  CAS  Google Scholar 

  18. Yatzidis H (1985) Clin Nephrol 23:63

    CAS  Google Scholar 

  19. Zakharov S, Navratil T, Pelclova D (2012) Basic Clin Pharmacol Toxicol 110:427

    Article  CAS  Google Scholar 

  20. Zakharov S, Navratil T, Pelclova D (2012) Ups J Med Sci 117:309

    Article  Google Scholar 

  21. Yu Z, Gu L, Pang H, Fang Y, Yan H, Fang W (2015) Case Rep Nephrol Dial 5:77

    Article  Google Scholar 

  22. Bryson DP (1996) Comprehensive reviews in toxicology: for emergency clinicians. CRC Press, p 361

  23. Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR (2006) Clin J Am Soc Nephrol 1:1161

    Article  CAS  Google Scholar 

  24. Pasch A, Schaffner T, Huynh-Do U, Frey BM, Frey FJ, Farese S (2008) Kidney Int 74:1444

    Article  CAS  Google Scholar 

  25. Hayden MR, Goldsmith DJ (2010) Sodium thiosulfate: new hope for the treatment of calciphylaxis. In: Seminars in dialysis, p 258

  26. New N, Mohandas J, John GT, Ratanjee S, Healy H, Francis L, Ranganathan D (2011) Int J Nephrol ID 982854

  27. Adirekkiat S, Sumethkul V, Ingsathit A, Domrongkitchaiporn S, Phakdeekitcharoen B, Kantachuvesiri S, Kitiyakara C, Klyprayong P, Disthabanchong S (2010) Nephrol Dial Transplant 25:1923

    Article  CAS  Google Scholar 

  28. Farah M, Crawford RI, Levin A, Yan CC (2011) Nephrol Dial Transplant 26:191

    Article  Google Scholar 

Download references

Acknowledgments

The authors acknowledge the financial support of the Projects of the Charles University in Prague P25/1LF/2 and P28/1LF/6.

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Authors and Affiliations

  1. Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Na Bojisti 1, 120 00, Prague 2, Czech Republic

    Jiri Hlusicka & Sergey Zakharov

  2. Department of Dialysis, Charles University in Prague and General University Hospital, U Nemocnice 2, 128 08, Prague 2, Czech Republic

    Eva Veisova

  3. Department of Internal medicine, Hospital Decin, U Nemocnice 604/1, 405 02, Decin, Czech Republic

    Martin Ullrych

  4. Department of Internal Medicine, Hospital Nachod, Purkynova 446, 574 01, Nachod, Czech Republic

    Jaroslav Kubecek

  5. J. Heyrovský Institute of Physical Chemistry of the AS CRv.v.i., Dolejškova, 3182 23, Prague 8, Czech Republic

    Tomas Navratil

Authors
  1. Jiri Hlusicka
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  2. Eva Veisova
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  3. Martin Ullrych
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  4. Jaroslav Kubecek
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  5. Tomas Navratil
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  6. Sergey Zakharov
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Corresponding author

Correspondence to Jiri Hlusicka.

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The study was approved by the General University Hospital Ethics Committee in Prague, Czech Republic.

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Hlusicka, J., Veisova, E., Ullrych, M. et al. Serum calcium and phosphorus concentrations and the outcome of calciphylaxis treatment with sodium thiosulfate. Monatsh Chem 148, 435–440 (2017). https://doi.org/10.1007/s00706-016-1850-3

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  • DOI: https://doi.org/10.1007/s00706-016-1850-3

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