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Synthesis, Characterization and MRI Application of Cobalt-Zinc Ferrite Nanoparticles Coated with DMSA: An In-vivo Study

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Abstract

The aim of this study was to synthesize and characterize the dimercaptosuccinic acid (DMSA) cobalt–zinc (Co–Zn) ferrite magnetic nanoparticles (NPs) and their efficiency as a contrast agent in in vivo MR imaging of rat liver. Co–Zn ferrite NPs were synthesized by the thermal decomposition method and stabilized by DMSA. The NPs were characterized by different analyses to study their physical and magnetic properties and were injected into 6 adult male rats. Liver MRI was performed to measure the signal intensity at different times. The average nanoparticle size was estimated at about 8 ± 1 nm using transmission electron microscopy (TEM). The r2 and r2* relaxivity of these particles were obtained at 32.85 and 168.96 mmol L−1 s−1, respectively, using an agarose phantom imaged by MRI. In the in vivo condition, injection of SNPs (2.5 mg Fe/kg) showed negative contrast in a way that for T2 and T2* weighted the maximum contrast enhancement was 58.46 and 77.13%, respectively. Regarding our results, the synthesized Co–Zn ferrite NPs stabilized by DMSA are appropriate agents for increasing the contrast in both T2 and T2* weighted based on MR imaging in rat liver.

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Acknowledgments

This article was extracted from a master's thesis in Medical Physics by the first author and it was supported by Shiraz University of Medical Sciences (grant number: 8833 and ethical committee consent number: IR.SUMS.REC.1394.S919). The authors would like to thank the center of Comparative and Experimental Medicine at Shiraz University of Medical Sciences, and the MRI center of Faghihi Hospital (Shiraz, Iran).

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Authors and Affiliations

  1. Department of Medical Physics and Medical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Leyla Ansari, Farideh Momeni & Alireza Mehdizadeh

  2. Department of Material Engineering, Faculty of Engineering, Shahrekord University, Shahrekord, Iran

    Ibrahim Sharifi

  3. Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran

    Hadis Ghadrijan & Naser Rasouli

  4. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Negar Azarpira

  5. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Negar Azarpira

  6. Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Hamed Zamani

  7. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mahdi Mohammadi

  8. Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran

    Alireza Mehdizadeh

  9. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

    Razzagh Abedi-Firouzjah

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  1. Leyla Ansari
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Correspondence to Alireza Mehdizadeh or Razzagh Abedi-Firouzjah.

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Ansari, L., Sharifi, I., Ghadrijan, H. et al. Synthesis, Characterization and MRI Application of Cobalt-Zinc Ferrite Nanoparticles Coated with DMSA: An In-vivo Study. Appl Magn Reson 52, 33–45 (2021). https://doi.org/10.1007/s00723-020-01220-2

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  • DOI: https://doi.org/10.1007/s00723-020-01220-2

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