Abstract
Energy drink consumption has been anecdotally linked to the development of adverse cardiovascular effects in consumers, although clinical trials to support this link are lacking. The effects of Red Bull® energy drink on cardiovascular and neurologic functions were examined in college-aged students enrolled at Winona State University. In a double-blind experiment where normal calorie and low calorie Red Bull® were compared to normal and low calorie placebos, no changes in overall cardiovascular function nor blood glucose (mg/dL) were recorded in any participant (n = 68) throughout a 2-h test period. However, in the second experiment, nine male and twelve female participants subjected to a cold pressor test (CPT) before and after Red Bull® consumption showed a significant increase in blood sugar levels pre- and post Red Bull® consumption. There was a significant increase in diastolic blood pressure of the male volunteers immediately after submersion of the hand in the 5°C water for the CPT. Under the influence of Red Bull®, the increase in diastolic pressure for the male participants during the CPT was negated. There were no significant changes in the blood pressure of the female participants for the CPT with or without Red Bull®. Finally, the CPT was used to evaluate pain threshold and pain tolerance before and after Red Bull® consumption. Red Bull® consumption was associated with a significant increase in pain tolerance in all participants. These findings suggest that Red Bull® consumption ameliorates changes in blood pressure during stressful experiences and increases the participants’ pain tolerance.
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References
Alford C, Cox H et al (2001) The effects of Red Bull energy drink on human performance and mood. Amino Acids 21:139–150. doi:10.1007/s007260170021
Baum M, Weiss M (2001) The influence of taurine containing drink on cardiac parameters before and after exercise measured by echocardiography. Amino Acids 20:75–82. doi:10.1007/s007260170067
Bichler A, Swenson A et al (2006) A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure. Amino Acids 31:471–476. doi:10.1007/s00726-005-0302-x
Boyle M, Castillo V (2006) Monster on the loose. Fortune 154:116–122
Clayfield M (2008) Red Bull may boost heart disease risk. The Australian (14 August 2008), Melborne. http://www.theaustralian.news.come.au/story/0,24183664-23289,00html. Accessed 17 Dec 2008
Fillingim R, Maixner W (1995) Gender differences in response to noxious stimuli. Pain Forum 4:209–221
Geiss KR, Jester I et al (1994) The effect of taurine-containing drink on performance in 10 endurance-athletes. Amino Acids 7:45–56. doi:10.1007/BF00808445
Greene M, Boltax A et al (1965) Circulatory dynamics during the cold pressor test. Am J Cardiol 16:54–60. doi:10.1016/0002-9149(65)90007-X
Hines EA Jr, Brown GE (1932) A standard stimulus for measuring vasomotor reactions: its application in the study of hypertension. Staff Meetings of the Mayo Clinic 8:332–335
Huxtable R, Bressler R (1973) Effect of taurine on a muscle intracellular membrane. Biochim Biophys Acta 323:573–583. doi:10.1016/0005-2736(73)90165-X
Kotke K, Gehrke K (2008) Sports and energy drinks. J Ren Nutr 18(2):e1–e8. doi:10.1053/j.jrn.2007.10.034
Lafleche AB, Pannier BM et al (1998) Arterial response during cold pressor test in borderline hypertension. Am J Physiol 275(Heart Circ Physiol 44):H409–H415
Lane JD (1983) Caffeine and cardiovascular responses to stress. Psychosom Med 45(5):447–451
Lane JD, Williams R (1985) Caffeine affects cardiovascular responses to stress. Psychophysiology 22:648–655. doi:10.1111/j.1469-8986.1985.tb01662.x
Lane JD, Williams R (1987) Cardiovasclar effects of caffeine and stress in regular coffee drinkers. Psychophysiology 24:157–164. doi:10.1111/j.1469-8986.1987.tb00271.x
Lane JD, Adcock A et al (1990) Caffeine effect on cardiovascular and neuroendocrine responses to acute pyschosocial stress and their relationship to level of habitual caffeine consumption. Psychosom Med 52:320–336
Lovallo WR, Pincomb G et al (1989) Caffeine may potentiate adrenocortical stress response in hypertension-prone men. Hypertension 14:170–176
Maixner W et al (1982) Factors influencing the altered pain perception in the spontaneously hypertensive rat. Brain Res 237(1):137–145
Mal’Chikova L, Elizarova E (1981) Taurine and cAMP content in the heart. Kardiologiya 21:85–89
Mal’Chikova L, Speranskaia N et al (1979) Effect of Taurine on the cAMP and cGMP content in the rat heart in stress. Biull Eksp Biol Med 87:134–137
Malinauskas BM, Aeby VG et al (2007) A survey of energy drink consumption patterns among college students. Nutr J 31(6):35. doi:10.1186/1475-2891-6-35
Mitchell LA, MacDonald RAR et al (2004) Temperature and the cold pressor test. J Pain 5(4):233–237. doi:10.1016/j.jpain.2004.03.004
Norquist C (2008) French ban on Red Bull (drink) upheld by European Court. http://www.medicalnewstoday.com/articles/5753.php. Accessed 17 Nov 2008
Öz E, Erbas D et al (1999) Taurine and calcium interaction in protection of myocardium exposed to ischemic reperfusion injury. Gen Pharmacol 33(2):137–141. doi:10.1016/S0306-3623(98)00284-5
Palmer D (2008) France reluctantly lifts ban on Red Bull. Australian Food News. http://www.ausfoodnews.com.au/2008/07/17/france-reluctantly-lifts-ban-on-red-bull.html. Retrieved 6 Jan 2009
Pasantes-Morales H, Martin D et al (1982) Taurine activation of a bicarbonate-dependent, ATP-supported calcium uptake in frog rod outer segments. Neurochem Res 7:317–328. doi:10.1007/BF00965643
Passmore A, Kondowe G et al (1987) Renal and cardiovascular effects of caffeine: a dose response study. Clin Sci 72:749–756
Pepino MY, Mennella JA (2005) Sucrose-induced analgesia is related to sweet preferences in children but not adults. Pain 119(1–3):210–218. doi:10.1016/j.pain.2005.09.029
Pincomb G, Lovallo WR et al (1985) Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men. Am J Cardiol 56:119–122. doi:10.1016/0002-9149(85)90578-8
Reiser MF, Ferris EBJ (1947) The nature of the cold pressor test and its significance in relation to neurogenic and humoral mechanisms in hypertension. J Clin Invest 27(1):156–183. doi:10.1172/JCI101919
Reissig CJ, Strain EC et al. (2008) Caffeinated energy drinks—a growing problem. Drug Alcohol Depend (in press)
Riley J, Robinson M et al (1998) Sex differences in the perception of noxious experimental stimuli: a meta analysis. Pain 74:181–187. doi:10.1016/S0304-3959(97)00199-1
Robertson D, Frolich J et al (1978) Effects of caffeine on plasma renin activity, catecholamines and blood pressure. N Engl J Med 298:181–186
Satoh H (1998) Modulatons by taurine of the spontaneous action potentials in right atrial muscles of rats. Gen Pharmacol 30(2):209–212. doi:10.1016/S0306-3623(97)85720-5
Shirlow M (1983) Patterns of caffeine consumption. Hum Nutr Appl Nutr 37:307–313
Sung B, Lovallo W et al (1990) Effects of caffeine on blood pressure response during exercise in normotensive health young men. Am J Cardiol 65:909–913. doi:10.1016/0002-9149(90)91435-9
Tandy J (2008) France ends 12-year ban on energy drink Red Bull. Reuters 15 Jul 2008. http://www.reuters.com/article/healthNews/idUSL1576964720080715?feedType=RSS&feedName=healthNews. Accessed on 18 May 2009
Whitsett T, Manion C et al (1984) Cardiovascular effects of coffee and caffeine. Am J Cardiol 53:918. doi:10.1016/0002-9149(84)90525-3
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Ragsdale, F.R., Gronli, T.D., Batool, N. et al. Effect of Red Bull energy drink on cardiovascular and renal function. Amino Acids 38, 1193–1200 (2010). https://doi.org/10.1007/s00726-009-0330-z
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DOI: https://doi.org/10.1007/s00726-009-0330-z