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Supportive Therapie in der Radioonkologie

Supportive therapy in radiation oncology

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Der Onkologe Aims and scope

Zusammenfassung

Hintergrund

Entscheidend für den Erfolg der Strahlentherapie ist die zeitgerechte Applikation ohne toxizitätsbedingte Pausen; eine effektive Supportivtherapie ist obligat.

Fragestellung

Es werden Prophylaxe und Therapie akuter/subakuter Strahlenfolgen beschrieben.

Methoden

Von 1995 bis 2011 publizierte Studien wurden systematisch analysiert und die Leitlinie „Supportive Maßnahmen der Radioonkologie“ der Deutschen Gesellschaft für Radioonkologie erstellt.

Ergebnisse

Prophylaxe und Therapie der (sub)akuten Strahlenreaktion werden für Bestrahlungen des Zerebrums, im Kopf-Hals-Bereich, der Lunge und der Haut dargestellt.

Schlussfolgerung

Strahlentherapiepausen können durch leitliniengerechte Supportivtherapie vermieden werden. Bei Verdacht auf Nebenwirkungen sollten die Patienten in der Radioonkologie vorgestellt werden.

Abstract

Background

Radiotherapy is effective if applied in a timely manner. Supportive therapy is necessary to avoid toxicity-related treatment interruptions.

Objective

To describe evidence-based supportive therapy in radiation oncology.

Methoden

Studies published in 1995–2011 were systematically analyzed and guidelines were defined.

Results

The prevention and therapy of (sub)acute radiation side effects of the cerebrum, head and neck region, skin and lungs are described.

Conclusion

Guideline conform supportive therapy mitigates side effects and avoids interruptions in radiation therapy. Patients with suspected radiation side effects should present to a radiation oncology department.

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Literatur

  1. Ainsbury EA, Bouffler SD, Dörr W et al (2009) Radiation cataractogenesis: a review of recent studies. Radiat Res 172:1–9

    Article  CAS  PubMed  Google Scholar 

  2. Alexiou GA, Tsiouris S, Kyritsis AP et al (2009) Glioma recurrence versus radiation necrosis: accuracy of current imaging modalities. J Neurooncol 95:1–11

    Article  PubMed  Google Scholar 

  3. Antonadou D, Coliarakis N, Synodinou M et al (2001) Randomized phase III trial of radiation treatment +/- amifostine in patients with advanced-stage lung cancer. Int J Radiat Oncol Biol Phys 51:915–922

    Article  CAS  PubMed  Google Scholar 

  4. Bostrom A, Lindman H, Swartling C et al (2001) Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother Oncol 59:257–265

    Article  CAS  PubMed  Google Scholar 

  5. Butler JM Jr, Case LD, Atkins J et al (2007) A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy. Int J Radiat Oncol Biol Phys 69:1496–1501

    Article  CAS  PubMed  Google Scholar 

  6. Dörr W, Herrmann T (2007) Efficacy of Wobe-Mugos E for reduction of oral mucositis after radiotherapy: results of a prospective, randomized, placebo-controlled, triple-blind phase III multicenter study. Strahlenther Onkol 183:121–127

    Article  PubMed  Google Scholar 

  7. Epstein JB, Silverman S Jr, Paggiarino DA et al (2001) Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. Cancer 92:875–885

    Article  CAS  PubMed  Google Scholar 

  8. Feyer PC, Maranzano E, Molassiotis A et al (2011) Radiotherapy-induced nausea and vomiting (RINV): MASCC/ESMO guideline for antiemetics in radiotherapy: update 2009. Support Care Cancer 19(Suppl 1):S5–S14

    Article  PubMed  Google Scholar 

  9. Gerstner ER, McNamara MB, Norden AD et al (2009) Effect of adding temozolomide to radiation therapy on the incidence of pseudo-progression. J Neurooncol 94:97–101

    Article  CAS  PubMed  Google Scholar 

  10. Hoeller U (2011) Radiotherapy-induced adverse events. Elsevier, Philadelphia

  11. Hoeller U, Belka C, Frank B et al (2014) Supportive Maßnahmen in der Radioonkologie – S2e Leitlinie. In: AWMF

  12. Holler U, Schubert T, Budach V et al (2013) Blisters – an unusual effect during radiotherapy. Strahlenther Onkol 189:977–979

    Article  CAS  PubMed  Google Scholar 

  13. Inoue A, Kunitoh H, Sekine I et al (2001) Radiation pneumonitis in lung cancer patients: a retrospective study of risk factors and the long-term prognosis. Int J Radiat Oncol Biol Phys 49:649–655

    Article  CAS  PubMed  Google Scholar 

  14. Keefe DM, Schubert MM, Elting LS et al (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109:820–831

    Article  CAS  PubMed  Google Scholar 

  15. Lalla RV, Bowen J, Barasch A et al (2014) MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer 120:1453–1461

    PubMed Central  PubMed  Google Scholar 

  16. Lind J, Senan S, Smit E (2012) Pulmonary toxicity after bevacizumab and concurrent thoracic radiotherapy observed in a phase I study for inoperable stage III non-small-cell lung. J Clin Oncol 30

  17. Mak SS, Molassiotis A, Wan WM et al (2000) The effects of hydrocolloid dressing and gentian violet on radiation-induced moist desquamation wound healing. Cancer Nurs 23:220–229

    Article  CAS  PubMed  Google Scholar 

  18. Matuschek C, Bölke E, Nawatny J et al (2011) Bevacizumab as a treatment option for radiation-induced cerebral necrosis. Strahlenther Onkol 187:135–139

    Article  PubMed  Google Scholar 

  19. Nicolatou-Galitis O, Sarri T, Bowen J et al (2013) Systematic review of amifostine for the management of oral mucositis in cancer patients. Support Care Cancer 21:357–364

    Article  PubMed  Google Scholar 

  20. Niedner R (1990) Local therapy of the poorly healing wound. Med Monatsschr Pharm 13:340–348

    CAS  PubMed  Google Scholar 

  21. Özturk B, Egehan I, Atavci S et al (2004) Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial. Int J Radiat Oncol Biol Phys 58:213–219

    Article  PubMed  Google Scholar 

  22. Pagel J, Mohorn M, Kloetzer KH et al (1998) The inhalation versus systemic prevention of pneumonitis during thoracic irradiation. Strahlenther Onkol 174:25–29

    Article  CAS  PubMed  Google Scholar 

  23. Pommier P, Gomez F, Sunyach MP et al (2004) Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 22:1447–1453

    Article  CAS  PubMed  Google Scholar 

  24. Riesenbeck D, Herrmann T (2000) Lunge und Bronchialsystem. In: Herrmann T, Dörr W (Hrsg) Nebenwirkungen in der Radioonkologie. Urban und Vogel, München

  25. Scott C, Suh J, Stea B et al (2007) Improved survival, quality of life, and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole-brain radiation therapy for brain metastases. Am J Clin Oncol 30:580–587

    Article  CAS  PubMed  Google Scholar 

  26. Sharp L, Finnila K, Johansson H et al (2013) No differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions – results from a randomised blinded trial. Eur J Oncol Nurs 17:429–435

    Article  PubMed  Google Scholar 

  27. Soffietti R, Cornu P, Delattre JY et al (2006) EFNS guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force. Eur J Neurol 13:674–681

    Article  CAS  PubMed  Google Scholar 

  28. Soussain C, Ricard D, Fike JR et al (2009) CNS complications of radiotherapy and chemotherapy. Lancet 374:1639–1651

    Article  CAS  PubMed  Google Scholar 

  29. Werner-Wasik M, Axelrod RS, Friedland DP et al (2002) Phase II trial of twice weekly amifostine in patients with non-small cell lung cancer treated with chemoradiotherapy. Semin Radiat Oncol 12:34–39

    Article  PubMed  Google Scholar 

  30. Yarnold J, Brotons MC (2010) Pathogenetic mechanisms in radiation fibrosis. Radiother Oncol 97:149–161

    Article  CAS  PubMed  Google Scholar 

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Einhaltung ethischer Richtlinien

Interessenkonflikt. Keiner der Autoren hat einen Interessenkonflikt. Der Beitrag enthält keine Studien an Menschen oder Tieren.

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Correspondence to U. Höller.

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Höller, U., Schubert, T. Supportive Therapie in der Radioonkologie. Onkologe 21, 318–322 (2015). https://doi.org/10.1007/s00761-014-2797-9

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  • DOI: https://doi.org/10.1007/s00761-014-2797-9

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