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Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy

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Abstract

Alzheimer’s disease (AD) is a type of neurodegenerative malady that is associated with the accumulation of amyloid plaques. Metal ions are critical for the development and upkeep of brain activity, but metal dyshomeostasis can contribute to the development of neurodegenerative diseases, including AD. This review highlights the association between metal dyshomeostasis and AD pathology, the feasibility of rebalancing metal homeostasis as a therapeutic strategy for AD, and a survey of current drugs that action via rebalancing metal homeostasis. Finally, we discuss the challenges that should be overcome by researchers in the future to enable the practical use of metal homeostasis rebalancing agents for clinical application.

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Abbreviations

AD:

Alzheimer’s disease

Aβ:

Amyloid-beta

BBB:

Blood–brain barrier

CNS:

Central nervous system

APP:

Amyloid precursor protein

ROS:

Reactive oxygen species

8HQ:

8-Hydroxyquinoline

CQ:

Clioquinol

DFP:

Deferiprone

TETA:

Trientine

DFO:

Desferrioxamine

EGCG:

(−)-Epigallocatechin-3-gallate

BACE1:

β-Secretase

AChE:

Acetylcholinesterase

NMDA:

N-Methyl-d-aspartic acid

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Acknowledgements

This work is supported by Hong Kong Baptist University (FRG2/17-18/003, China), the Health and Medical Research Fund (HMRF/14150561, China), the National Natural Science Foundation of China (21575121 and 21775131, China), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018 (China), the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03, China), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/17-18/03, China), Collaborative Research Fund (C5026-16G, China), SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04, China), the Funded by The Science and Technology Development Fund, Macau SAR (File no. 077/2016/A2 and SKL-QRCM-2017-2019) and the University of Macau (MYRG2016-00151-ICMS-QRCM and MYRG2018-00187-ICMS, China).

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  1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, Macau SAR, China

    Guan‐Jun Yang & Chung-Hang Leung

  2. Department of Chemistry, Hong Kong Baptist University, Kowloon, 999077, Hong Kong SAR, China

    Hao Liu & Dik-Lung Ma

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Yang, G., Liu, H., Ma, DL. et al. Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy. J Biol Inorg Chem 24, 1159–1170 (2019). https://doi.org/10.1007/s00775-019-01712-y

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  • DOI: https://doi.org/10.1007/s00775-019-01712-y

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