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Selective determination of L-dopa in the presence of ascorbic acid and uric acid using a 3D graphene foam

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Abstract

Three-dimensional interconnected network graphene foam (GF) was synthesized by chemical vapor deposition. The GF was transferred onto indium tin oxide glass, acting as an electrode for the selective determination of L-dopa in the presence of ascorbic and uric acid. Using differential pulse voltammetry (DPV) method, the oxidation peak current is well linear with L-dopa concentration in the range of 0.05–1 μM with a sensitivity of 2.64 μA μM−1 and in the range of 1–40 μM with a sensitivity of 1.82 μA μM−1. The detection limit of this electrode for L-dopa is about 20 nM. The proposed electrode can also effectively avoid the interference of ascorbic acid and uric acid, making the proposed sensor suitable for the accurate determination of L-dopa in human urine fluids. This electrode will have a wide range of potential application prospect in electrochemical detection.

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Funding

This work is supported by the National Natural Science Foundation of China (51201052), Science Funds for the Young Innovative Talents of HUST (201306) and Postdoctoral Initial Founding of Heilongjiang Province (LBH-Q1260, LBH-Q14117).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, 150040, Harbin, People’s Republic of China

    Hong Yan Yue, Hong Zhang, Shuo Huang, Xin Gao, Jing Chang, Xuan Yu Lin, Long Hui Yao, Li Ping Wang & Er Jun Guo

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, 150001, Harbin, People’s Republic of China

    Shuo Huang

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  1. Hong Yan Yue
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  2. Hong Zhang
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  3. Shuo Huang
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  4. Xin Gao
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  9. Er Jun Guo
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Correspondence to Hong Yan Yue.

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Yue, H.Y., Zhang, H., Huang, S. et al. Selective determination of L-dopa in the presence of ascorbic acid and uric acid using a 3D graphene foam. J Solid State Electrochem 22, 3527–3533 (2018). https://doi.org/10.1007/s10008-018-4047-3

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  • DOI: https://doi.org/10.1007/s10008-018-4047-3

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