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Serum resistin levels in patients with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis

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Abstract

The purpose of this meta-analysis was to investigate whether serum resistin level was associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) by comparing serum resistin levels between RA or SLE patients and normal controls. PubMed and EMBASE databases (up to May 13, 2014) were used to search all related articles. The weighted mean differences (WMDs) with 95 % confidence interval (CI) were calculated using random-effect model analysis. The Cochrane Q test and I 2 statistic were used to test heterogeneity. To assess publication bias, the Egger’s test and visual observation of a funnel plot were used. The Newcastle-Ottawa scale was used to assess the study quality. The STATA statistical software (version 11.0) was applied to deal with statistical data. A total of eight studies of RA including 620 patients and 460 healthy controls, and six studies of SLE including 559 patients and 430 healthy controls were finally included in the meta-analysis. The results revealed that the serum resistin levels in RA were significantly higher than those in normal controls (WMD = 0.767 ng/ml, 95 % CI = 0.114–1.419, P = 0.021), but there was no significant difference between SLE patients and normal controls (WMD = 2.771 ng/ml, 95 % CI = −0.521–6.063, P = 0.099). Publication bias was undetected. In conclusion, this meta-analysis indicate that serum resistin level was significantly elevated in RA patients.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81172764)

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    Authors and Affiliations

    1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People’s Republic of China

      Qing Huang, Sha-Sha Tao, Yu-Jing Zhang, Chao Zhang, Lian-Ju Li, Wei Zhao, Meng-Qin Zhao, Peng Li, Hai-Feng Pan & Dong-Qing Ye

    2. Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People’s Republic of China

      Qing Huang, Sha-Sha Tao, Yu-Jing Zhang, Chao Zhang, Lian-Ju Li, Wei Zhao, Meng-Qin Zhao, Peng Li, Hai-Feng Pan & Dong-Qing Ye

    3. Division of Epidemiology, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, People’s Republic of China

      Chen Mao

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    1. Qing Huang
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    Correspondence to Dong-Qing Ye.

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    Qing Huang and Sha-Sha Tao contributed equally to this work.

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    Huang, Q., Tao, SS., Zhang, YJ. et al. Serum resistin levels in patients with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Clin Rheumatol 34, 1713–1720 (2015). https://doi.org/10.1007/s10067-015-2955-5

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    • DOI: https://doi.org/10.1007/s10067-015-2955-5

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