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The Chinese version of the SLEQOL is a reliable assessment of health-related quality of life in Han Chinese patients with systemic lupus erythematosus

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Abstract

To assess the health-related quality of life (HRQOL) of Han Chinese people with systemic lupus erythematosus (SLE) using a Chinese version of the Systemic Lupus Erythematosus-Specific Quality of Life Questionnaire (SLEQOL-C) and explore the factors influencing HRQOL of people with SLE. Participants were Han Chinese people with SLE. The SLEQOL-C and 36-item Short Form Health Survey (SF-36) were used to estimate the HRQOL. Disease activity was determined using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and fatigue using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F). Participant factors included age, gender, educational background, disease duration, erythrocyte sedimentation rate (ESR), and complement C3 and C4 levels. The results showed that higher SLEQQL-C scores correlated with lower SF-36 both measures are essential for HRQQL prediction. The SLEQOL-C scores were correlated with educational level,age, FACIT-F score, SLEDAI score, and ESR, which suggests that poor educational background, old-age, and increased fatigue, disease activity, and ESR might represent poor HRQOL. Although disease duration did not significantly correlate with the scores on the SLEQOL-C; those whose disease duration was 12–24 months had higher SLEQOL-C summary scores and physical functioning, symptoms, and treatment subscale scores than did those whose duration was less than 6 months. The FACIT-F score, education level, age, disease duration, SLEDAI score, and ESR contributed to SLEQOL-C scores. The SLEQOL-C is reliable for assessing HRQOL of Han Chinese people with SLE. Fatigue, educational level, age, disease duration, ESR, and disease activity mainly influenced HRQOL of SLE patients.

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Funding

This research was supported by grants from the Education Department of Heilongjiang Province (grant number 12531239).

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  1. Hai-Zhi Jiang and Zhi-Guo Lin, contributed equally to this article.

Authors and Affiliations

  1. Department of Rheumatology and Immunology, the First Affiliated Hospital of Harbin Medical University, Youzheng Road 23, Nangang District, Harbin, 150001, People’s Republic of China

    Hai-Zhi Jiang, Zhi-Guo Lin, Hong-Juan Li, Qing -Du, Shu-Ya Wang, Shang-Qi Guan & Yi-Fang Mei

  2. Department of Rheumatology and Immunology, the First Hospital of Qiqihar City, Qiqihar, 161000, People’s Republic of China

    Wei -Tian

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  1. Hai-Zhi Jiang
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Contributions

Hai-Zhi Jiang, Zhi-Guo Lin, Hong-Juan Li, and Yi-Fang Mei conceived and designed the experiments; Hai-Zhi Jiang, Zhi-Guo Lin, Hong-Juan Li, Qing-Du, Wei-Tian, Shu-Ya Wang, Shang-Qi Guan, and Yi-Fang Mei performed the experiments; Hong-Juan Li and Shu-Ya Wang analyzed the data; Hai-Zhi Jiang and Shu-Ya Wang wrote the paper. Hai-Zhi Jiang and Zhi-Guo Lin contributed equally to this article.

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Correspondence to Yi-Fang Mei.

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Jiang, HZ., Lin, ZG., Li, HJ. et al. The Chinese version of the SLEQOL is a reliable assessment of health-related quality of life in Han Chinese patients with systemic lupus erythematosus. Clin Rheumatol 37, 151–160 (2018). https://doi.org/10.1007/s10067-017-3910-4

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