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Gene and miRNA expression in giant cell arteritis—a concise systematic review of significantly modified studies

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Abstract

Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.

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Funding

Funding for this work was obtained from the Slovenian Research Agency for the National Research Programme #P3-0314, the Austrian Ministry of Science, Research and Economy (HSRSM project OMICS Center Graz), and the Austrian Science Fund (FWF): T923-B26.

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Authors and Affiliations

  1. Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova cesta 62, 1000, Ljubljana, Slovenia

    Tadeja Kuret, Blaž Burja, Katja Lakota, Polona Žigon, Snezna Sodin-Semrl, Saša Čučnik, Matija Tomšič & Alojzija Hočevar

  2. Institute of Computational Biotechnology, Graz University of Technology, Petersgasse 14, 8010, Graz, Austria

    Julia Feichtinger & Gerhard G. Thallinger

  3. OMICS Center Graz, BioTechMed Graz, Stiftingtalstraße 24, 8010, Graz, Austria

    Julia Feichtinger & Gerhard G. Thallinger

  4. Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland

    Mojca Frank-Bertoncelj

  5. Faculty of Mathematics, Natural Science and Information Technologies, University of Primorska, Glagoljaška ulica 8, 6000, Koper, Slovenia

    Katja Lakota & Snezna Sodin-Semrl

  6. Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia

    Saša Čučnik

  7. Faculty of Medicine, University of Ljubljana, Korytkova ulica 2, 1000, Ljubljana, Slovenia

    Matija Tomšič

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  1. Tadeja Kuret
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  2. Blaž Burja
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Tadeja Kuret and Blaž Burja shared first authorship

Rheumatology in Slovenia: Clinical practice and translational research

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Kuret, T., Burja, B., Feichtinger, J. et al. Gene and miRNA expression in giant cell arteritis—a concise systematic review of significantly modified studies. Clin Rheumatol 38, 307–316 (2019). https://doi.org/10.1007/s10067-018-4231-y

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