Abstract
This study was conducted to compare flavonoids and anti-inflammatory effects in Korean Chrysanthemum species. Leaf samples were identified using HPLC/MS with five flavonoids: luteolin-7-O-rutinoside, luteolin-7-O glucoside, apigenin-7-O-glucoside, apigenin, and acacetin-7-O-rutinoside. Leaf extracts from four taxa dose-dependently suppressed LPS-stimulated NO production significantly (p<0.05) inhibited production of LPS-induced PGE2 compared with controls. The extracts reduced the LPS-induced expressions of inducible NO synthase and cyclooxygenase-2 and inhibited LPS-induced tumor necrosis factor-α and interleukin-6 production for anti-inflammatory effects.
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Kim, S.J., Lee, KT., Choi, HE. et al. Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages. Food Sci Biotechnol 24, 975–985 (2015). https://doi.org/10.1007/s10068-015-0125-9
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DOI: https://doi.org/10.1007/s10068-015-0125-9