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A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis

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Abstract

In this study, garlic powder, tomato extract and a mixture of both were analyzed for anti-thrombotic effects using a collagen and epinephrine induced thrombosis model. Rats were randomly assigned to control, thrombosis induced control (COL/EP), garlic powder (G), tomato extract (T) and mixture of garlic powder and tomato extract (GT) groups. Test materials were administered for 7 days and thrombosis was induced by collagen and epinephrine injection. The results showed that G, T, and GT delayed activated partial thromboplastin time and reduced the expression of intracellular adhesion molecule-1 mRNA. Histological analysis of aorta and lung revealed that thrombosis was partially improved by G, T, and GT. Although there was no synergistic effect in GT compared to G and T treatment, this study showed that G, T, and GT have anti-thrombotic effect.

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Acknowledgements

This work was carried out with the support of “Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01169502)” funded by Rural Development Administration, Republic of Korea.

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Authors and Affiliations

  1. Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul, 01811, Republic of Korea

    Leeseon Kim & Ji Yeon Kim

  2. Department of Nutritional Science and Food Management, Ewha Woman’s University, Seoul, 03760, Republic of Korea

    Yeni Lim, Soo-yeon Park, You Jin Kim & Oran Kwon

  3. Department of Food Science and Biotechnology, CHA University, Seongnam, Gyeonggido, 13488, Republic of Korea

    Jin Hee Lee

  4. Department of Biomedical Laboratory Science, Eulji University, Seongnam, Gyeonggido, 13135, Republic of Korea

    Jae-Ho Shin

  5. Department of Nutritional Science and Food Management, Soongeui Women’s College, Seoul, 04628, Republic of Korea

    Yoon Kyoung Yang

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  1. Leeseon Kim
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Correspondence to Ji Yeon Kim.

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Kim, L., Lim, Y., Park, Sy. et al. A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis. Food Sci Biotechnol 27, 1513–1518 (2018). https://doi.org/10.1007/s10068-018-0469-z

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  • DOI: https://doi.org/10.1007/s10068-018-0469-z

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