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Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine

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Abstract

There are limited studies evaluating the fibrinogen levels in patients with migraine. It remains unknown whether the levels of the haematological marker of thromboembolism, d-dimer, and the levels of galectin-3, which plays an important role in inflammation as a proinflammatory mediator, change during the attacks in patients with migraine. The present study aims to compare galectin-3, fibrinogen and d-dimer levels in patients with migraine during the attacks and interictal periods, and to compare galectin-3, fibrinogen and d-dimer levels between patients with migraine and healthy controls to investigate the role of these parameters in the pathogenesis of migraine. Fifty-nine patients with migraine and 30 age-gender matched healthy control subjects were enrolled in the study. Blood galectin-3, fibrinogen and d-dimer levels were measured in patients with migraine. Patients with migraine had higher levels of galectin-3, fibrinogen and d-dimer compared to the healthy controls (p < 0.05). No statistically significant difference was found between galectin-3 and fibrinogen levels during the attacks and interictal period in the migraine group (p > 0.05). Migraine patients had higher d-dimer levels during the attacks compared to the patients in the interictal period in the migraine group (p = 0.05). In conclusion, we found increased levels of fibrinogen, d-dimer and galectin-3 in patients with migraine compared to the healthy control group. Furthermore, we showed increased galectin-3 levels in patients with migraine, and higher d-dimer levels during migraine attacks compared to the interictal periods for the first time. These findings may be associated with the hypercoagulability and neurogenic inflammation during migraine headaches.

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Authors and Affiliations

  1. Department of Neurology, Dicle University School of Medicine, Diyarbakir, Turkey

    Yavuz Yucel, Adalet Arıkanoglu, Sefer Varol, Esref Akil & Ertugrul Uzar

  2. Department of Family Medicine, Dicle University School of Medicine, Diyarbakir, Turkey

    Halis Tanriverdi & Tahsin Celepkolu

  3. Department of Medical Biochemistry, Dicle University School of Medicine, Diyarbakir, Turkey

    Ibrahim Kaplan

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  1. Yavuz Yucel
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  2. Halis Tanriverdi
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  3. Adalet Arıkanoglu
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Correspondence to Yavuz Yucel.

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Yucel, Y., Tanriverdi, H., Arıkanoglu, A. et al. Increased fibrinogen, d-dimer and galectin-3 levels in patients with migraine. Neurol Sci 35, 545–549 (2014). https://doi.org/10.1007/s10072-013-1542-2

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  • DOI: https://doi.org/10.1007/s10072-013-1542-2

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