Abstract
Objective
Similar clinical characteristics of epilepsy and migraine and the prevalence of their comorbidity have been investigated for years. The present study investigated the relationship between epilepsy and headache.
Methods
A total of 420 epilepsy patients, who visited epilepsy outpatient clinic within 6-month period between January 2016 and June 2016, were questioned whether they have headache. Age, gender, duration of epilepsy, type of seizures, and temporal relationship of headache with seizure were investigated in the patients with headache.
Results
Headache was detected in 111 (26%) of 420 epilepsy patients. The prevalence of migraine was 15%. When the temporal relationship of headache with seizure was evaluated, interictal headache was found to be the most common type with a percentage of 74.8%. No significant difference was determined between the patients with migraine and non-migraine headache in terms of age, gender, duration of epilepsy, age at the onset of epilepsy, type of seizure, and electroencephalography findings. The prevalence of interictal headache was statistically significantly higher in migraine patients as compared to that of non-migraine patients (p < 0.001); however, the prevalence of preictal headache and the prevalence of postictal headache were significantly lower (p = 0.001 and p < 0.001, respectively).
Conclusion
The prevalence of headache and the prevalence of migraine, which are considered to be pathogenetically linked to epilepsy, were not different in epilepsy patients as compared to that of the general population. Different outcomes and percentages in other studies suggest that pathogenesis of headache is multifactorial and that different diagnostic criteria might have been taken into consideration.
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References
Kim DW, Lee SK (2017) Headache and epilepsy. J Epilepsy Res 7:7–15
Velioğlu SK, Yüzgül N (2010) The association between epilepsy and migraine. In: Epilepsi, vol 16, pp 167–172 [Article in Turkish]
Andermann E, Andermann F (1987) Migraine-epilepsy relationships: epidemiological and genetic aspects. In: Andermann F, Lugaresi E (eds) Migraine and epilepsy. Butterworths, Boston, pp 281–291
Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808
Chang RS, Leung CYW, Ho CCA, Yung A (2017) Classifications of seizures and epilepsies, where are we? - A brief historical review and update. J Formos Med Assoc 116:736–741
Schon F, Blau JN (1987) Post-epileptic headache and migraine. J Neurol Neurosurg Psychiatry 50:1148–1152
Ito M, Nakamura F, Honma H, Takeda Y, Kobayashi R, Miyamoto T, Koyama T (1999) A comparison of post-ictal headache between patients with occipital lobe epilepsy and temporal lobe epilepsy. Seizure 8:343–346
Leniger T, Isbruch K, von den Driesch S, Diener HC, Hufnagel A (2001) Seizure-associated headache in epilepsy. Epilepsia 42:1176–1179
Karaali-Savrun F, Goksan B, Yeni SN, Uzun N (2002) Seizure-related headache in patients with epilepsy. Seizure 11:67–69
Ito M, Adachi N, Nakamura F, Koyama T, Okamura T, Kato M, Kanemoto K, Nakano T, Matsuura M, Hara S (2004) Characteristics of postictal headache in patients with partial epilepsy. Cephalalgia 24:23–28
Stovner LJ, Hagen K, Jensen R, Katsarava Z, Lipton RB, Scher AI, Steiner TJ, Zwart JA (2007) The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 27:193–210
Aydin Özemir Z, Baykan B (2013) The face of chronic migraine which has started to be clarified. Noro Psikiyatr Ars 50(Suppl 1):S21–S25
Brodtkorb E, Bakken IJ, Sjaastad O (2008) Comorbidity of migraine and epilepsy in a Norwegian community. Eur J Neurol 15:1421–1423
Gameleira FT, Ataíde L Jr, Raposo MC (2013) Relations between epileptic seizures and headaches. Seizure 22:622–626
Ottman R, Lipton RB (1994) Comorbidity of migraine and epilepsy. Neurology 44:2105–2110
Velioğlu SK, Ozmenoğlu M (1999) Migraine-related seizures in an epileptic population. Cephalalgia 19:797–801 discussion 766
Wang XQ, Lang SY, He MW, Zhang X, Zhu F, Dai W, Shi XB, Wan M, Ma YF, Chen YN, Yu SY (2014) High prevalence of headaches in patients with epilepsy. J Headache Pain 15:70
Ito M, Adachi N, Nakamura F, Koyama T, Okamura T, Kato M, Kanemoto K, Nakano T, Matsuura M, Hara S (2003) Multi-center study on post-ictal headache in patients with localization-related epilepsy. Psychiatry Clin Neurosci 57:385–389
HELP Study Group (2010) Multi-center study on migraine and seizure-related headache in patients with epilepsy. Yonsei Med J 51:219–224
Kwan P, Man CB, Leung H, Yu E, Wong KS (2008) Headache in patients with epilepsy: a prospective incidence study. Epilepsia 49:1099–1102
Mainieri G, Cevoli S, Giannini G, Zummo L, Leta C, Broli M, Ferri L, Santucci M, Posar A, Avoni P, Cortelli P, Tinuper P, Bisulli F (2015) Headache in epilepsy: prevalence and clinical features. J Headache Pain 16:556
Poleon S, Szaflarski JP (2017) Photosensitivity in generalized epilepsies. Epilepsy Behav 68:225–233
De Simone R, Ranieri A, Marano E, Beneduce L, Ripa P, Bilo L, Meo R, Bonavita V (2007) Migraine and epilepsy: clinical and pathophysiological relations. Neurol Sci 28(Suppl 2):S150–S155
Ambrosini A (2018) Neurophysiology of migraine. Neurol Sci 39(Suppl 1):59–60
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