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Aspergillus thyroiditis: a review of the literature to highlight clinical challenges

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Abstract

Aspergillus involvement of the thyroid is the most commonly reported fungal thyroiditis. Aspergillus thyroiditis (AT) has primarily been a postmortem diagnosis in immunocompromised patients with diagnosed disseminated invasive Aspergillus or high suspicion of fungal infection during life. With better treatment modalities for the comorbidities that place patients at high risk for fungal infections, as well as better antifungal therapies for Aspergillus infections specifically, the spectrum of disease and presentation of AT may be shifting from what was primarily a postmortem finding to an antemortem diagnosis, necessitating a high index of clinical suspicion and timely intervention. We present a review of the literature to better clarify clinical features, diagnostic modalities, and management considerations pertaining to this disease.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatrics, Loyola University Medical Center, Maywood, IL, USA

    J. Nguyen

  2. Department of Pediatric Hematology/Oncology, Loyola University Medical Center, Maywood, IL, USA

    R. Manera

  3. Pediatric Endocrinology, Loyola University Medical Center, Maywood, IL, USA

    C. Minutti

Authors
  1. J. Nguyen
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  2. R. Manera
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  3. C. Minutti
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Correspondence to J. Nguyen.

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Reviews Editor: W. van Leeuwen

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Nguyen, J., Manera, R. & Minutti, C. Aspergillus thyroiditis: a review of the literature to highlight clinical challenges. Eur J Clin Microbiol Infect Dis 31, 3259–3264 (2012). https://doi.org/10.1007/s10096-012-1704-9

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  • DOI: https://doi.org/10.1007/s10096-012-1704-9

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