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Characterizations and Photothermal Properties of Narrow Bandgap Conjugated Polymer Nanoparticles

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Abstract

Photothermal therapy (PTT) is a minimally invasive treatment that kills cancer cells by converting photon energy into heat. The past few decades have witnessed the booming development of photothermal materials, mainly focusing on precious metal nanomaterials and carbon nanomaterials, such as nanogold and silver and nanocarbon materials for near-infrared (NIR) light-triggered PTT. As precious metals are expensive and potentially harmful to humans, exploration and development of a new type of photothermal materials has become a research hotspot in this field. Herein, we report narrow bandgap conjugated polymer nanoparticles (PDPP NPs) based on pyrrolo[3,4-c]pyrrole-1,4-dione (DPP) with intense NIR absorption at 900 nm, as well as a photothermal energy conversion efficiency of 75%. This polymer nanoparticle is essentially non-toxic, as the cell viability of mouse remained more than 90%, even when the concentration of PDPP NPs was at 0.5 mg·mL−1.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (No. 21474105) and the Project of the Natural Science and En-gineering Research Council of Canada.

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Authors and Affiliations

  1. State Key Laboratory of Fine Chemicals, Department of Polymer Science & Materials, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China

    Yu-Lin Zhang, Huai-Yu Gao, Jia-Wei Liu, Wen-Jie Xia, Wen-Qiang Qiao & Zhi-Yuan Wang

  2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Jun-Tao Ren

  3. Department of Chemistry, Carleton University, Ontario, K1S 5B6, Canada

    Zhi-Yuan Wang

Authors
  1. Yu-Lin Zhang
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  2. Jun-Tao Ren
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  3. Huai-Yu Gao
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  4. Jia-Wei Liu
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  5. Wen-Jie Xia
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  6. Wen-Qiang Qiao
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Correspondence to Wen-Qiang Qiao or Zhi-Yuan Wang.

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Zhang, YL., Ren, JT., Gao, HY. et al. Characterizations and Photothermal Properties of Narrow Bandgap Conjugated Polymer Nanoparticles. Chin J Polym Sci 38, 814–818 (2020). https://doi.org/10.1007/s10118-020-2420-z

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  • DOI: https://doi.org/10.1007/s10118-020-2420-z

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