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Huge pedunculated angiomyofibroblastoma of the vulva

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Abstract

We present the case of a huge pedunculated benign mesenchymal myxoid tumor that developed on the right labia majora of a 48-year-old-woman. The excised mass weighed 4534 g and was 23 cm in diameter; the cut surface was yellowish and elastic. Microscopic examination revealed spindle and plump oval tumor cells arranged with abundant capillary vessels in an edematous stroma. Immunohistochemical staining showed that the tumor cells were positive for vimentin, desmin, estrogen receptor, and progesterone receptor, but negative for α-smooth muscle actin, CD34, CD45, CD68, and S-100. Based on these features, the pathological diagnosis was angiomyofibroblastoma. A pedunculated angiomyofibroblastoma is extremely rare and, to the best of our knowledge, this is the biggest such tumor in terms of size and weight reported to date. It is especially important in such a huge mass greater than 10 cm that angiomyofibroblastoma is differentiated from aggressive angiomyxoma, which is a deeply invasive and recurrent neoplasm.

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Conflict of interest statement

The authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Gynecology, Ibaraki Prefectural Central Hospital, 6528 Koibuchi, Kasama, Ibaraki, 309-1793, Japan

    Kimihiro Nagai

  2. Department of Plastic Surgery, Tsukuba University, Tukuba, Japan

    Koji Aadachi

  3. Department of Pathology, Ibaraki Prefectural Central Hospital, Kasama, Ibaraki, Japan

    Hitoaki Saito

Authors
  1. Kimihiro Nagai
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  2. Koji Aadachi
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  3. Hitoaki Saito
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Correspondence to Kimihiro Nagai.

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Nagai, K., Aadachi, K. & Saito, H. Huge pedunculated angiomyofibroblastoma of the vulva. Int J Clin Oncol 15, 201–205 (2010). https://doi.org/10.1007/s10147-010-0026-0

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  • DOI: https://doi.org/10.1007/s10147-010-0026-0

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