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Serum levels of bcl-2 in patients with colorectal cancer

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Techniques in Coloproctology Aims and scope Submit manuscript

Abstract

Background

Many recent studies focus on the immunohistochemical evaluation of Bcl-2 expression, and its prognostic significance in colorectal cancer (CRC). Our aim was to investigate the presence of bcl-2 protein in the serum and to examine the association between its levels, stage and tumour load, in patients with CRC.

Methods

A commercially available ELISA was used for the estimation of bcl-2 levels, in 94 patients with different stages of CRC. Forty-eight healthy blood donors served as controls. Concentrations ranging 2SD above and below the controls median were accepted as “normal”.

Results

bcl-2 was detected in the serum of patients with CRC. A significantly higher proportion of patients with non-metastatic disease (61%), had high serum bcl-2 values, compared to patients with metastatic disease (28%, p<0.0001).

Conclusions

Serum bcl-2 in patients with CRC may reflect the degree of Bcl-2 expression in cancer tissue. Serum bcl-2 is easily determinable, and could be useful as a prognostic marker in CRC.

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Authors and Affiliations

  1. 1 Alexandrou Svolou, 546 22, Thessaloniki, Greece

    K. Giannoulis

  2. 3rd Department of Surgery, AHEPA University Hospital, Thessaloniki, Greece

    K. Giannoulis & O. Gamvros

  3. 1st Department of Medicine, AHEPA University Hospital, Thessaloniki, Greece

    G. Fountzilas & E. Giannoulis

  4. Laboratory of Serology, AHEPA University Hospital, Thessaloniki, Greece

    N. Angouridakis & C. Angouridaki

Authors
  1. K. Giannoulis
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  2. G. Fountzilas
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  3. N. Angouridakis
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  4. C. Angouridaki
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  5. E. Giannoulis
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  6. O. Gamvros
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Corresponding author

Correspondence to K. Giannoulis.

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Giannoulis, K., Fountzilas, G., Angouridakis, N. et al. Serum levels of bcl-2 in patients with colorectal cancer. Tech Coloproctol 8 (Suppl 1), s56–s58 (2004). https://doi.org/10.1007/s10151-004-0112-2

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  • DOI: https://doi.org/10.1007/s10151-004-0112-2

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