Abstract
Background
The aim of this study is to assess the role of high fibre diet and aspirin on dimethylhydrazine (DMH)-induced colorectal cancer in rats.
Materials and methods
Colorectal tumours were induced with DMH. The animals were randomly divided into five groups (15 rats each): I, controls; II, rats receiving only the carcinogen; III, rats receiving the carcinogen and high fibre diet; IVA, rats receiving the carcinogen plus low dose aspirin; IVB, rats receiving the carcinogen plus high dose aspirin.
Results
Adenocarcinomas were detected in 100% of the rats in group II, 47% of the rats in group III (χ 2, p<0.05), 100% of the rats in group IVA, but the incidence was reduced to 50% in the rats of group IVB (p<0.05).
Conclusions
These data indicate that high fibre diet and aspirin suppress experimental colon carcinogenesis and the protective effect of aspirin is dose related.
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Miliaras, S., Miliaras, D., Vrettou, E. et al. The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study. Tech Coloproctol 8 (Suppl 1), s59–s61 (2004). https://doi.org/10.1007/s10151-004-0113-1
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DOI: https://doi.org/10.1007/s10151-004-0113-1