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Maternal exposure to high-fat and high-fructose diet evokes hypoadiponectinemia and kidney injury in rat offspring

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Abstract

Background

Maternal exposure to overnutrition during fetal development contributes to metabolic and renal damage in offspring. Adiponectin plays a protective role against obesity-related renal injury. However, role of adiponectin in renal injury of offspring exposed to maternal overnutrition remains unknown. We addressed the issue.

Methods

Female Sprague–Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating, and kept each diet during the gestation and lactation period. After 4 weeks postpartum, all the offspring were fed N diet, and followed by 12 weeks. Kidney weight, urinary albumin excretion, blood pressure, and blood chemistry, including adiponectin and malondialdehyde, a marker of oxidative stress, were evaluated in the offspring.

Results

Compared with N-offspring, serum adiponectin levels of 1-day- and 4-week-old HFF-offspring were significantly lower, the latter of which was inversely associated with malondialdehyde. Kidney weight was significantly decreased in 1-day-old HFF-offspring, whereas increased in 4-week-old HFF-offspring. Urinary albumin excretion levels of HFF-offspring at 8, 12, and 16-week old were significantly higher than those of N-offspring at the same age, whose levels at 16-week old were inversely correlated with plasma adiponectin. Compared with N-offspring, HFF-offspring at 16-week old exhibited glomerulosclerosis, hyperglycemia, and high mean blood pressure associated with reduced podocin and increased transforming growth factor-β1 expression in the kidneys.

Conclusions

Our present study suggests that exposure to maternal HFF-diet during fetal and early postnatal development induces hypoadiponectinemia in offspring, which might cause renal injury and metabolic derangements later in life.

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Acknowledgments

This work was supported, in part, by Grants-in-Aid for Welfare and Scientific Research (C) (No. 22590904) (K. F) and from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by MEXT-Supported Program for the Strategic Research Foundation at Private Universities, the Ministry of Education, Culture, Sports, Science and Technology (MEXT) (S. Y).

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Fukuoka, Japan

    Nana Yamada-Obara, Kensei Taguchi, Yusuke Kaida, Miyuki Yokoro, Yosuke Nakayama, Ryotaro Ando, Seiji Ueda, Seiya Okuda & Kei Fukami

  2. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan

    Sho-ichi Yamagishi & Takanori Matsui

  3. Medical Innovation Center, TMK Project, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Katsuhiko Asanuma

Authors
  1. Nana Yamada-Obara
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  2. Sho-ichi Yamagishi
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  3. Kensei Taguchi
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  4. Yusuke Kaida
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  12. Kei Fukami
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Correspondence to Kei Fukami.

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Yamada-Obara, N., Yamagishi, Si., Taguchi, K. et al. Maternal exposure to high-fat and high-fructose diet evokes hypoadiponectinemia and kidney injury in rat offspring. Clin Exp Nephrol 20, 853–861 (2016). https://doi.org/10.1007/s10157-016-1265-9

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  • DOI: https://doi.org/10.1007/s10157-016-1265-9

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