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The effects of SP110’s associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population

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Abstract

SP110 is a promising anti-Mycobacterium tuberculosis (MTB) gene. To investigate the effects of SP110 and its associated genes, i.e., MYBBP1A and RELA, on pathological progression of MTB infection, an association study with 424 patients of fresh pulmonary tuberculosis (PTB) and 424 healthy controls was performed. Moreover, classification and regression tree and multifactor dimensionality reduction were employed to explore the effects of gene–gene interactions on cavitary PTB. The results indicated that both the heterozygous genotype GC and homozygous genotype CC in rs3809849 had significant effects on the risk of PTB (OR 1.42, 95 % CI 1.06–1.92, p 0.019; OR 1.55, 95 % CI 1.04–2.33, p = 0.033, respectively), and heterozygous genotype CT in rs9061 also had similar effects (OR 1.43, 95 % CI 1.07–1.90, p = 0.014). The rs3809849 and rs9905742 in MYBBP1A were also significantly associated with cavitary PTB (p = 0.00046 and 0.039, respectively), while rs9061 in SP110 had no such association (p = 0.06931) except its significant association with non-cavitary PTB (p = 0.0093). The interaction of MYBBP1A and RELA had significant effect on cavitary PTB (OR 4.24, 95 % CI 1.44–12.49, p = 0.005). These suggest that MYBBP1A instead of SP110 may be a genetic risk factor for cavitary PTB and play important effects on its whole progress.

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Abbreviations

MTB:

Mycobacterium tuberculosis

MYBBP1A:

MYB-binding protein

MDR:

Multifactor dimensionality reduction

CART:

Classification and regression tree

LR:

Logistic regression

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Acknowledgments

The authors thank all study participants for their donation of blood samples. This work was supported by the National Infectious Disease Prevention and Cure Special Project (No. 2013ZX10003006-003-002), the National Nature Science Foundation of China (No. 31101015), the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (No. 81421061) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (no.12Z102050009).

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    Authors and Affiliations

    1. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 55 Guangyuanxi Road, Shanghai, 200030, China

      Shi-Yao Jiang, Chun-Ling Wan, Lin He & Lei Cai

    2. Department of Laboratory Medicine, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, 10 Changjiangzhilu, Daping, Chongqing, 400022, China

      Shi-Yao Jiang & Shao-Li Deng

    3. Shanghai Key Laboratory of Mycobacterium Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

      Jun Yue

    4. College of Life Science, Anhui Normal University, Wuhu, 241000, AnHui, China

      Lin-Lin Li & Chao Yang

    5. Department of Infectious Diseases, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China

      Wen-zhong Chen

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    1. Shi-Yao Jiang
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    Correspondence to Lei Cai or Shao-Li Deng.

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    Shi-Yao Jiang and Lin-Lin Li have contributed equally to this work.

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    Jiang, SY., Li, LL., Yue, J. et al. The effects of SP110’s associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population. Clin Exp Med 16, 219–225 (2016). https://doi.org/10.1007/s10238-015-0339-4

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