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Diminution de l’expression du virus d’Epstein Barr (EBV) dans la muqueuse gingivale par la prise durant deux mois de Ganoderma lucidum, Coriolus versicolor et Lentinus edodes

Decreased expression of EBV in gingival mucosa after a treatment of two months with Ganoderma lucidum, Coriolus versicolor and Lentinus edodes

  • Mycothérapie
  • Published:
Phytothérapie

Résumé

Une étude randomisée en simple aveugle a été réalisée pour évaluer l’efficacité de l’association Ganoderma lucidum+Coriolus versicolor+Lentinus edodes (GCL ; 61 patients) donnée pendant deux mois versus placebo sous la forme de Laetiporus sulfureus avec un mélange de 8 huiles essentielles (LS+HE ; seulement 1/8e de goutte d’HE/j ; 32 patients) sur la disparition du portage buccal d’EBV. GCL diminue de 80,3% le portage EBV buccal versus 6,3% pour le mélange LS+HE (p<0,001). Ce mélange de trois mycelia est très prometteur pour la prévention du portage chronique actif d’EBV. Cette étude préliminaire doit être complétée, pour vérifier ce résultat et pour répondre à de nombreuses questions émergentes : nécessité d’un traitement prolongé pour maintenir la disparition virale ? Effet de GCL sur les co-infections virales intrabuccales ?

Abstract

A randomised single-blind study was performed to investigate the efficacy of Ganoderma lucidum +Coriolus versicolor+Lentinus edodes (GCL; 61 patients), given two months, versus placebo i.e. Laetiporus sulfureus associated with eight essential oils (LS+HE; only 1/8 drop per day; 32 patients) against the oral reactivation of EBV with detectable DNA-EBV in oral swabs. GCL decreased by 80.3% le presence of DNA-EBV in oral swabs versus 6.3% for LS+HE (p<0.001). GCL is a harmless and promising association of mycelia which could prevent EBV induced-diseases. This preliminary study should be completed in order to increase the number of inclusions and confirm this finding. Additional queries may be tackled: should prevention require prolonged therapy with reduced dosage or may GCL participate to the eradication of other viruses such as papillomavirus, HSV1, HSV2 or cytomegalovirus?

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Authors and Affiliations

  1. Gastro-entérologue hépatologue (DES) ; cancérologue (DESC) ; immunologue (DEA/DESC), 40, rue du Dr Roux, 51350, Cormontreuil, France

    B. Donatini

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  1. B. Donatini
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Correspondence to B. Donatini.

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Donatini, B. Diminution de l’expression du virus d’Epstein Barr (EBV) dans la muqueuse gingivale par la prise durant deux mois de Ganoderma lucidum, Coriolus versicolor et Lentinus edodes . Phytothérapie 13, 231–233 (2015). https://doi.org/10.1007/s10298-015-0952-4

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  • DOI: https://doi.org/10.1007/s10298-015-0952-4

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