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Non-invasive pulmonary perfusion assessment in young patients with cystic fibrosis using an arterial spin labeling MR technique at 1.5 T

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Abstract

Object

To assess lung perfusion in young patients with cystic fibrosis (CF) using an arterial spin labeling (ASL) technique.

Materials and methods

Perfusion imaging was performed in 5 healthy volunteers and 33 pediatric patients (13 ± 5 years) with CF using an ASL technique. Image quality was evaluated on a five-point scale (1 = excellent). Quantitative perfusion maps were calculated based on the modified Bloch equations. Perfusion differences between volunteers and CF patients and regional differences between lobes were analyzed using Student’s t test. The association of perfusion values and forced expiratory volume in 1 s (FEV1) was analyzed using univariate regression analysis.

Results

Mean lung perfusion was 698 ± 67 ml/100g/min (range: 593–777 ml/100g/min) in volunteers and 526 ± 113 ml/100g/min (range: 346–724 ml/100g/min) in CF patients. Median image quality was 2 in volunteers and 3 in CF patients. In CF patients, significantly lower perfusion was observed in the upper lobes compared to healthy volunteers. Mean perfusion values significantly correlated with FEV1 (r = 0.84, P < 0.0001).

Conclusion

ASL perfusion imaging provides lung perfusion assessment in young CF patients. This non-invasive functional imaging technique is worth being evaluated in the clinical monitoring of CF patients.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany

    Christina Schraml, Nina F. Schwenzer, Andreas Boss, Susanne Schäfer, Claus D. Claussen & Jürgen F. Schäfer

  2. Section on Experimental Radiology, University Hospital of Tuebingen, Tuebingen, Germany

    Christina Schraml, Nina F. Schwenzer, Petros Martirosian, Andreas Boss & Fritz Schick

  3. Hoppe-Seyler-Str. 1, 72076, Tuebingen, Germany

    Martin Stern

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  1. Christina Schraml
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  2. Nina F. Schwenzer
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  3. Petros Martirosian
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  4. Andreas Boss
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  5. Fritz Schick
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  6. Susanne Schäfer
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  7. Martin Stern
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  9. Jürgen F. Schäfer
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Correspondence to Christina Schraml.

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Schraml, C., Schwenzer, N.F., Martirosian, P. et al. Non-invasive pulmonary perfusion assessment in young patients with cystic fibrosis using an arterial spin labeling MR technique at 1.5 T. Magn Reson Mater Phy 25, 155–162 (2012). https://doi.org/10.1007/s10334-011-0271-x

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  • DOI: https://doi.org/10.1007/s10334-011-0271-x

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