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A Novel Methodology for the Simulation of Athletic Tasks on Cadaveric Knee Joints with Respect to In Vivo Kinematics

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Abstract

Six degree of freedom (6-DOF) robotic manipulators have simulated clinical tests and gait on cadaveric knees to examine knee biomechanics. However, these activities do not necessarily emulate the kinematics and kinetics that lead to anterior cruciate ligament (ACL) rupture. The purpose of this study was to determine the techniques needed to derive reproducible, in vitro simulations from in vivo skin-marker kinematics recorded during simulated athletic tasks. Input of raw, in vivo, skin-marker-derived motion capture kinematics consistently resulted in specimen failure. The protocol described in this study developed an in-depth methodology to adapt in vivo kinematic recordings into 6-DOF knee motion simulations for drop vertical jumps and sidestep cutting. Our simulation method repeatably produced kinetics consistent with vertical ground reaction patterns while preserving specimen integrity. Athletic task simulation represents an advancement that allows investigators to examine ACL-intact and graft biomechanics during motions that generate greater kinetics, and the athletic tasks are more representative of documented cases of ligament rupture. Establishment of baseline functional mechanics within the knee joint during athletic tasks will serve to advance the prevention, repair and rehabilitation of ACL injuries.

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Acknowledgments

This work was supported by the National Institutes of Health/NIAMS Grants #R01-AR049735, #R01-AR05563, #R01-AR056660 and #R01-AR056259. The authors would also like to acknowledge the support of the staff at the Sports Health and Performance Institute at The Ohio State University and the Sports Medicine Biodynamics Laboratory at Cincinnati Children’s Hospital.

Conflict of interest

There were no conflicts of interest in the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, USA

    Nathaniel A. Bates, Rebecca J. Nesbitt, Jason T. Shearn & Timothy E. Hewett

  2. Sports Medicine Biodynamics Center, Division of Sports Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Nathaniel A. Bates, Gregory D. Myer & Timothy E. Hewett

  3. The Sports Health and Performance Institute, The Ohio State University, Columbus, OH, USA

    Nathaniel A. Bates & Timothy E. Hewett

  4. Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA

    Gregory D. Myer & Timothy E. Hewett

  5. Department of Orthopaedic Surgery, College of Medicine, University of Cincinnati, Cincinnati, OH, USA

    Gregory D. Myer

  6. The Micheli Center for Sports Injury Prevention, Boston, USA

    Gregory D. Myer

  7. Departments of Physiology and Cell Biology, Orthopaedic Surgery, Family Medicine, and Biomedical Engineering, The Ohio State University, Columbus, OH, USA

    Timothy E. Hewett

  8. OSU Sports Medicine, 2050 Kenny Road, Suite 3100, Columbus, OH, 43221, USA

    Timothy E. Hewett

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  1. Nathaniel A. Bates
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Correspondence to Timothy E. Hewett.

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Associate Editor Cato Laurencin oversaw the review of this article.

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Bates, N.A., Nesbitt, R.J., Shearn, J.T. et al. A Novel Methodology for the Simulation of Athletic Tasks on Cadaveric Knee Joints with Respect to In Vivo Kinematics. Ann Biomed Eng 43, 2456–2466 (2015). https://doi.org/10.1007/s10439-015-1285-8

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  • DOI: https://doi.org/10.1007/s10439-015-1285-8

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