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Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography

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Abstract

Biomechanical properties are important for the cornea to maintain its normal shape and function. There is still a need to develop better methods for accurate measurement of corneal mechanical properties. In this study, we propose to introduce the optical coherence tomography (OCT) in inflation test for the imaging of corneal deformation in order to measure its biomechanical properties. Ten cornea-mimicking silicone phantoms with different stiffness and five fresh porcine corneas were tested using the proposed method. Intra-ocular pressure was changed from 10 to 90 mmHg using two different loading rates to observe the pressure-apex displacement relationship and calculate the apparent stiffness of the corneas. Stiffness of the corneal phantoms obtained by the inflation test ranged from 0.2 to 1 MPa, which was highly consistent with the results from the mechanical tensile test (y = 0.70x, p < 0.001). The porcine corneas showed highly viscoelastic behavior with obvious hysteresis in inflation. The apparent stiffness of the porcine corneas was 0.63 ± 0.07 and 1.05 ± 0.08 MPa with loading rates of 3.3 and 33 mmHg/min, respectively. Mapping of corneal surface displacement was also generated for both the phantom and porcine corneas. This study showed that it is feasible to incorporate the high resolution OCT imaging in inflation test to measure the biomechanical properties of the cornea.

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Acknowledgments

This study was partly supported by grants from the National Natural Science Foundation of China (31600758), Beijing Natural Science Foundation (7174287), Beijing Nova Program (xx2018076) and Beijing Municipal Administration of Hospitals’ Youth Programme (QMS20170204). The authors would like to thank Ms. Sally Ding for editing the manuscript. No conflict of interest exists.

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Author notes

  1. Like Wang and Lei Tian have contributed equally to this work.

Authors and Affiliations

  1. Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China

    Like Wang, Yanping Huang & Yongping Zheng

  2. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory; National Engineering Research Center for Ophthalmology, Beijing, 100730, China

    Lei Tian

  3. School of Physics and Optoelectronic Engineering, Foshan University, Foshan, 528000, China

    Yanping Huang

  4. Department of Ophthalmology, Chinese PLA General Hospital, Beijing, 100853, China

    Yifei Huang

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  1. Like Wang
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Correspondence to Yanping Huang or Yongping Zheng.

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Associate Editor Tingrui Pan oversaw the review of this article.

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Wang, L., Tian, L., Huang, Y. et al. Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography. Ann Biomed Eng 46, 247–256 (2018). https://doi.org/10.1007/s10439-017-1973-7

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  • DOI: https://doi.org/10.1007/s10439-017-1973-7

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