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Survival of rats with experimental chronic heart failure depending on pharmacodynamic and pharmacokinetic parameters of angiotensin-converting enzyme inhibitors and β-adrenoceptor blockers

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. β-Adrenoceptor blockers without intrinsic sympathomimetic activity not only prolonged 6-month survival and lifetime, but also decreased the mortality rate of rats with decompensation of chronic heart failure.

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Authors and Affiliations

  1. Department of Pharmacology, Department of Biology, Department of Normal Physiology, Yaroslavl State Medical Academy, Russia

    V. N. Fedorov, E. V. Sal’nikov, A. V. Sidorov, A. V. Bogatushin & M. M. Fateev

Authors
  1. V. N. Fedorov
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  2. E. V. Sal’nikov
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  3. A. V. Sidorov
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  4. A. V. Bogatushin
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  5. M. M. Fateev
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Corresponding author

Correspondence to M. M. Fateev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 1, pp. 45–48, January, 2006

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Fedorov, V.N., Sal’nikov, E.V., Sidorov, A.V. et al. Survival of rats with experimental chronic heart failure depending on pharmacodynamic and pharmacokinetic parameters of angiotensin-converting enzyme inhibitors and β-adrenoceptor blockers. Bull Exp Biol Med 141, 40–43 (2006). https://doi.org/10.1007/s10517-006-0088-1

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  • DOI: https://doi.org/10.1007/s10517-006-0088-1

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