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Administration of LPS-Stimulated Autologous Macrophages Induces α-Synuclein Aggregation in Dopaminergic Neurons of Rat Brain

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Administration of autologous macrophages isolated from the abdominal cavity and stimulated in vitro with bacterial LPS to rats increased blood level of antibodies against α-synuclein. Antibody titer reached its maximum during week 5 of the experiment and exceeded the levels of anti-α-synuclein antibodies appeared in response to transplantation of non-stimulated macrophages. Brain immunohistochemistry showed that additional administration of LPS (250 μg/kg) to animals during week 4 after injection of LPS-stimulated macrophages led to α-synuclein accumulation in 9.4±3.2% dopaminergic neurons of the substantia nigra. These findings attest to induction of humoral immune response to α-synuclein in rats after administration of autologous LPS-stimulated macrophages, which can affect α-synuclein metabolism in dopaminergic neurons of the brain.

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References

  1. A. Abeliovich, Y. Schmitz, I. Farinas, et al., Neuron, 25, No. 1, 239–252 (2000).

    Article  PubMed  CAS  Google Scholar 

  2. A. Chen, S. M. Zhang, M. A. Hernan, et al., Arch. Neurol., 60, No. 8, 1059–1064 (2003).

    Article  PubMed  Google Scholar 

  3. E. Maries, B. Dass, T. J. Collier, et al., Nat. Rev. Neurosci., 4, No. 9, 727–738 (2003).

    Article  PubMed  CAS  Google Scholar 

  4. A. Mcenerney-Leo, D. W. Hadley, K. Gwinn-Hardy, J. Hardy, Mov. Disord., 20, No. 1, 1–10 (2005).

    Article  Google Scholar 

  5. C. F. Orr, D. B. Rowe, Y. Mizuno, et al., Brain, 128, No. 11, 2665–2674 (2005).

    Article  PubMed  Google Scholar 

  6. M. A. Salkeni, J. L. Lynch, T. Otamis-Price, W. A. Banks, J. Neuroimmune Pharmacol., 4, No. 2, 276–282 (2009).

    Article  PubMed  Google Scholar 

  7. K. Tanji, F. Mori, T. Imaizumi, et al., Pathol. Int., 52, No. 9, 572–577 (2002).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Udmurt State University, Izhevsk, Russia

    T. N. Sergeyeva & V. G. Sergeyev

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  1. T. N. Sergeyeva
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  2. V. G. Sergeyev
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Correspondence to V. G. Sergeyev.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 10, pp. 376–378, October, 2010.

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Sergeyeva, T.N., Sergeyev, V.G. Administration of LPS-Stimulated Autologous Macrophages Induces α-Synuclein Aggregation in Dopaminergic Neurons of Rat Brain. Bull Exp Biol Med 150, 406–408 (2011). https://doi.org/10.1007/s10517-011-1153-y

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  • DOI: https://doi.org/10.1007/s10517-011-1153-y

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