We studied parameters of specific receptor binding of D2-dopamine receptor ligand [3H]-sulpiride and NMDA-receptor ligand [3H]-MK-801 on the membranes of striatum cells in Krushinsky–Molodkina rats (predisposed to audiogenic seizures) and strain “0” selected for the absence of audiogenic seizures. No interstrain differences were observed in affinity (Kd) of both D2- and NMDA-receptors to ligands. At the same time, significant interstrain differences in receptor density (Bmax) were found for both D2-receptors and NMDA-receptors. The reduced number of dopamine and glutamate receptors in the striatum can be associated with neurological peculiarities of Krushinsky–Molodkina rat strain (audiogenic seizures and postictal catalepsy).
Similar content being viewed by others
References
G. I. Kovalev, D. A. Abaimov, M. V. Voronin, et al., Neirokhimia, 24, No. 2, 150–156 (2007).
A. F. Semiokhina, I. B. Fedotova, and I. I. Poletaeva, Zh. Vyssh. Nerv. Deyat., 56, No. 2, 249–267 (2006).
A. Ya. Sorokin, V. S. Kudrin, P. M. Klodt, et al., Genetika, 40, No. 6, 688–690 (2004).
I. B. Fedotova, N. M. Surina, L. A. Malikova, et al., Zh. Vyssh. Nerv. Deyat., 58, No. 5, 620–627 (2008).
S. J. Kanes, B. A. Hitzemann, and R. J. Hitzemann, Pharmacol. Exp. Ther., 267, No. 1, 538–547 (1993).
S. A. Lipton, NeuroRx., 1, No. 1, 101–110 (2004).
M. S. Myslobodsky, M. Mintz, and O. Kofman, Pharmacol. Biochem. Behav., 15, No. 1, 93–100 (1981).
D. O. Seo, C. Y. Shin, J. R. Ryu, et al., Eur. J. Pharmacol., 396, Nos. 2–3, 53–58 (2000).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 158–160, August, 2012
Rights and permissions
About this article
Cite this article
Firstova, J.J., Abaimov, D.A., Surina, N.M. et al. Binding of Specific Ligand by D2- and NMDA-Receptors of Striatum Cells in Two Rat Strains Predisposed and Resistant to Audiogenic Seizures. Bull Exp Biol Med 154, 196–198 (2012). https://doi.org/10.1007/s10517-012-1910-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-012-1910-6