A comparative analysis of the direct effects of amphetamine and methamphetamine exposure on BV2 microglia cells in the presence and absence of cellular debris was performed. A significant dose-dependent and treatment-dependent effect of amphetamine and methamphetamine on BV2 cells was demonstrated: methamphetamine, but not amphetamine, inhibited phagocytosis, and a differential regulation of cytokines was observed in response to amphetamine and methamphetamine.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 154, No. 8, pp. 192-191, August, 2012
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Shanks, R.A., Anderson, J.R., Taylor, J.R. et al. Amphetamine and Methamphetamine Have a Direct and Differential Effect on BV2 Microglia Cells. Bull Exp Biol Med 154, 228–232 (2012). https://doi.org/10.1007/s10517-012-1919-x
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DOI: https://doi.org/10.1007/s10517-012-1919-x