Morphological signs of early interstitial fi brosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fi brosis was confirmed by an increase in the number of lung cells expressing TNF-α. These changes were recorded in the presence of a many-fold increase in the counts of macrophages and fi broblasts expressing FGF, EGF, and their receptors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 12, pp. 803-807, December, 2013
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Anikina, A.G., Shkurupii, V.A., Potapova, O.V. et al. Expression of Profi brotic Growth Factors and Their Receptors by Mouse Lung Macrophages and Fibroblasts under Conditions of Acute Viral Infl ammation in Infl uenza A/H5N1 Virus. Bull Exp Biol Med 156, 833–837 (2014). https://doi.org/10.1007/s10517-014-2463-7
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DOI: https://doi.org/10.1007/s10517-014-2463-7