Abstract
As life expectancy increases worldwide, ageing and age-related diseases arise as a major issue for societies around the globe. Understanding the biological mechanisms underlying the ageing process is thus instrumental for the development of efficient interventions aimed to prevent and treat age-related conditions. Current knowledge in the biogerontology field points to epigenetics as a critical component of the ageing process, not only by serving as a bona-fide marker of biological age but also by controlling and conferring inheritability to cellular and organismal ageing. This is reflected by a myriad of evidences demonstrating the relationship between DNA methylation, histone modifications, chromatin remodeling and small non-coding RNAs and several age-related phenotypes. Given the reversibility of epigenetic alterations, epigenetic reprogramming may also be envisioned as a potential approach to treat age-related disorders. Here we review how different types of epigenetic mechanisms are involved in the ageing process. In addition, we highlight how interventions modulate epigenetics and thus promote health- and lifespan.
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The authors are funded by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (2019/14391-8, 2018/11672-3, 2018/11792-9, 2017/08829-5, 2017/01184-9, and 2017/22057-5), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (310287/2018-9), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.143923/2017-00 and scholarships).
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Braga, D.L., Mousovich-Neto, F., Tonon-da-Silva, G. et al. Epigenetic changes during ageing and their underlying mechanisms. Biogerontology 21, 423–443 (2020). https://doi.org/10.1007/s10522-020-09874-y
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DOI: https://doi.org/10.1007/s10522-020-09874-y