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A Validation Study of Adiponectin rs266729 Gene Variant with Type 2 Diabetes, Obesity, and Metabolic Phenotypes in a Taiwanese Population

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Abstract

Previous data suggesting that a single nucleotide polymorphism (SNP), rs266729, in the adiponectin C1Q and collagen domain containing (ADIPOQ) gene was associated with type 2 diabetes (T2D) have been inconsistent, especially in Asian populations. In this replication study, we aimed to reassess whether the ADIPOQ rs266729 SNP is associated with T2D, obesity, and T2D/obesity-related metabolic traits in a Taiwanese population. A total of 1047 Taiwanese subjects were analyzed. The ADIPOQ rs266729 SNP was genotyped by the Taqman assay. T2D/obesity-related metabolic traits such as triglyceride, waist circumference, systolic and diastolic blood pressure, total cholesterol, creatinine, alanine aminotransferase, and fasting glucose were measured. Our data revealed that the ADIPOQ rs266729 SNP exhibited no association with T2D among the subjects. In addition, no evidence for an association with obesity (BMI ≧27 kg/m2) was found for the ADIPOQ rs266729 SNP. Moreover, the ADIPOQ rs266729 SNP did not show any association with T2D/obesity-related metabolic traits among the complete subjects. However, we found an effect modification of obesity on the association between the ADIPOQ rs266729 SNP and total cholesterol (P = 0.00068) only in obese participants after adjusting for age, gender, BMI, and T2D status. Our study indicates that the ADIPOQ rs266729 SNP may influence T2D/obesity-related metabolic traits such as total cholesterol in obese Taiwanese subjects (but not in non-obese subjects).

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Acknowledgments

The authors would like to thank Dr. Hua-Mei Chang of Vita Genomics, Dr. Yuchi Hwang of Vita Genomics, Dr. Dee Pei of the Cardinal Tien Hospital, Dr. Yi-Jen Hung of the Tri-Service General Hospital, and Dr. Shi-Wen Kuo of the Buddhist Xindian Tzu Chi General Hospital for research collaboration.

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Authors and Affiliations

  1. College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan

    Tun-Jen Hsiao

  2. Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

    Eugene Lin

  3. Vita Genomics, Inc., 7 Fl., No. 6, Sec. 1, Jung-Shing Road, Wugu Shiang, Taipei, Taiwan

    Eugene Lin

  4. TickleFish Systems Corporation, Seattle, WA, USA

    Eugene Lin

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  1. Tun-Jen Hsiao
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  2. Eugene Lin
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Correspondence to Eugene Lin.

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The authors declare that they have no conflict of interest.

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The authors extend their sincere thanks to Vita Genomics, Inc. and SBIR Grants from the Department of Economic Affairs in Taiwan for funding this research.

Human and Animal Rights Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Hsiao, TJ., Lin, E. A Validation Study of Adiponectin rs266729 Gene Variant with Type 2 Diabetes, Obesity, and Metabolic Phenotypes in a Taiwanese Population. Biochem Genet 54, 830–841 (2016). https://doi.org/10.1007/s10528-016-9760-y

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  • DOI: https://doi.org/10.1007/s10528-016-9760-y

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