Skip to main content
SpringerLink
Log in

Influence of bovine lactoferrin on selected probiotic bacteria and intestinal pathogens

  • Published:
BioMetals Aims and scope Submit manuscript

Abstract

This study investigated the effects of bovine lactoferrin (BLf) on the growth of different groups of bacteria in vitro. BLf showed a significant inhibitory effect on the growth of selected pathogens but not probiotics. BLf, in combination with probiotics, has the potential to influence the composition of the gut microflora via inhibition of intestinal pathogens with no significant effect on probiotic bacteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Arques JL, Fernandez J, Gaya P, Nunez M, Rodriguez E, Medina M (2004) Antimicrobial activity of reuterin in combination with nisin against food-borne pathogens. Int J Food Microbiol 95:225–229

    Article  CAS  PubMed  Google Scholar 

  • Artym J, Zimecki M (2005) The role of lactoferrin in the proper development of newborns. Postepy Hig Med Dosw (Online) 59:421–432

    Google Scholar 

  • Bullen JJ (1976) Iron-binding proteins and other factors in milk responsible for resistance to Escherichia coli. Ciba Found Symp 42:149–169

    CAS  PubMed  Google Scholar 

  • Cardoso LS, Araujo MI, Goes AM, Pacifico LG, Oliveira RR, Oliveira SC (2007) Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact 6:1

    Article  PubMed  Google Scholar 

  • Chen CY, Nace GW, Irwin PL (2003) A 6 × 6 drop plate method for simultaneous colony counting and MPN enumeration of Campylobacter jejuni, Listeria monocytogenes, and Escherichia coli. J Microbiol Methods 55:475–479

    Article  CAS  PubMed  Google Scholar 

  • Coppa GV, Zampini L, Galeazzi T, Gabrielli O (2006) Prebiotics in human milk: a review. Dig Liver Dis 38(Suppl 2):S291–S294

    Article  PubMed  Google Scholar 

  • Levay PF, Viljoen M (1995) Lactoferrin: a general review. Haematologica 80:252–267

    CAS  PubMed  Google Scholar 

  • Murdock CA, Cleveland J, Matthews KR, Chikindas ML (2007) The synergistic effect of nisin and lactoferrin on the inhibition of Listeria monocytogenes and Escherichia coli O157:H7. Lett Appl Microbiol 44:255–261

    Article  CAS  PubMed  Google Scholar 

  • Rosendale DI, Maddox IS, Miles MC, Rodier M, Skinner M, Sutherland J (2008) High-throughput microbial bioassays to screen potential New Zealand functional food ingredients intended to manage the growth of probiotic and pathogenic gut bacteria. Int J Food Sci Technol 43:2257–2267

    Article  CAS  Google Scholar 

  • Talarico TL, Casas IA, Chung TC, Dobrogosz WJ (1988) Production and isolation of reuterin, a growth inhibitor produced by Lactobacillus reuteri. Antimicrob Agents Chemother 32:1854–1858

    CAS  PubMed  Google Scholar 

  • Tang Z, Yin Y, Zhang Y et al (2009) Effects of dietary supplementation with an expressed fusion peptide bovine lactoferricin-lactoferrampin on performance, immune function and intestinal mucosal morphology in piglets weaned at age 21 d. Br J Nutr 101:998–1005

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was funded by a Technology in Industry Fellowship to H.T., awarded by the NZFRST, and by Drapac Ltd. The experimental work was carried out by H.T. under the supervision of her PhD supervisors, I.S.M, L.R.F and Q.S.

Author information

Authors and Affiliations

  1. School of Engineering and Advanced Technology, College of Sciences, Massey University, Auckland, New Zealand

    Hong Tian & Ian S. Maddox

  2. Department of Nutrition, School of Medical Sciences, The University of Auckland, Auckland, New Zealand

    Lynnette R. Ferguson

  3. Bioactives Research New Zealand, Auckland, New Zealand

    Hong Tian & Quan Shu

Authors
  1. Hong Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ian S. Maddox
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lynnette R. Ferguson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Quan Shu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ian S. Maddox.

Additional information

All authors contributed to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tian, H., Maddox, I.S., Ferguson, L.R. et al. Influence of bovine lactoferrin on selected probiotic bacteria and intestinal pathogens. Biometals 23, 593–596 (2010). https://doi.org/10.1007/s10534-010-9318-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10534-010-9318-0

Keywords

Search

Navigation