Abstract
Background
While screening has been demonstrated to reduce breast cancer mortality, the optimal screening interval is unknown. We designed a study to determine the risk of an advanced breast cancer diagnosis by varying the interval between mammograms.
Methods
We reviewed a single state’s mammography records of women diagnosed with breast cancer between 1994 and 2002. The pre-diagnosis screening interval was the number of days between the last two eligible mammograms preceding a cancer diagnosis. The interval was classified as annual (0.75–1.49 years), biennial (1.5–2.49 years) or longer (exceeding 2.49 years). Advanced breast cancer was ≥stage IIB, tumor size >2 cm, or ≥one lymph node with cancer.
Results
The probability of an advanced breast cancer␣diagnosis did not differ between women with an annual pre-diagnosis screening interval and women with a biennial interval (21.1% vs. 23.7%, P = 0.262). A longer pre-diagnosis screening interval was weakly associated with advanced breast cancer (21.8% for intervals 0.75–2.49 years vs. 26.8% for longer intervals,␣P = 0.070). In multivariate analysis, we found an␣interaction between the pre-diagnosis screening interval and age. Among women 50 years or older, the risk of an advanced breast cancer diagnosis risk was higher for women with a pre-diagnosis screening interval exceeding 2.49 years compared to women with shorter screening intervals (OR 1.99 [1.02–3.90]).
Conclusions
We found no difference in advanced breast cancer rates between women using mammography annually or biennially. Among women 50 years or older, the advanced breast cancer rate increased when the pre-diagnosis screening interval exceeded 2.49 years.
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References
Berry DA, Cronin KA, Plevritis SK, et al (2005) Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 353:1784–1792
Screening for breast cancer: recommendations and rationale (2002) Ann Intern Med 137:344–346
Smith RA, Saslow D, Sawyer KA, et al (2003) American Cancer Society guidelines for breast cancer screening: update 2003. CA Cancer J Clin 53:141–169
White E, Miglioretti DL, Yankaskas BC, et al (2004) Biennial versus annual mammography and the risk of late-stage breast cancer. J Natl Cancer Inst 96:1832–1839
Poplack SP, Tosteson AN, Grove MR, et al (2000) Mammography in 53,803 women from the New Hampshire mammography network. Radiology 217:832–840
Geller BM, Worden JK, Ashley JA, et al (1996) Multipurpose statewide breast cancer surveillance system: the Vermont experience. J Registry Manage 23:168–174
Berg WA, Campassi C, Langenberg P, et al (2000) Breast Imaging Reporting and Data System: inter- and intraobserver variability in feature analysis and final assessment. AJR Am J Roentgenol 174:1769–1777
Woodward WA, Strom EA, Tucker SL, et al (2003) Changes in the 2003 American Joint Committee on Cancer staging for breast cancer dramatically affect stage-specific survival. J␣Clin Oncol 21:3244–3248
Schairer C, Mink PJ, Carroll L, et al (2004) Probabilities of death from breast cancer and other causes among female breast cancer patients. J Natl Cancer Inst 96:1311–1321
Mokbel K (2005) Contemporary treatment of ductal carcinoma in situ of the breast. Med Sci Monit 11:RA86–RA93
StataCorp (2005) Stata statistical software, release 9. StataCorp LP. College Station, TX
Vacek PM, Geller BM, Weaver DL, et al (2002) Increased mammography use and its impact on earlier breast cancer detection in Vermont, 1975–1999. Cancer 94:2160–2168
U.S. Preventive Services Task Force. Recommendations and rationale: screening for breast cancer (2002). Available at http://www.ahrq.gov/clinic/3rduspstf/breastcancer/brcanrr.htm. Cited 8 May 2006
Pinto AE, Mendonca E, Andre S, et al (2002) Independent prognostic value of hormone receptor expression and S-phase fraction in advanced breast cancer. Anal Quant Cytol Histol 24:345–354
Furberg H, Millikan R, Dressler L, Newman B, Geradts J (2001) Tumor characteristics in African American and white women. Breast Cancer Res Treat 68:33–43
Salazar EL, Calzada L, Pedron N (1996) Infiltrating ductal / lobular carcinoma: an evaluation of prognostic factors in primary breast cancer. Arch AIDS Res 10:73–82
Leitch AM, Dodd GD, Costanza M, et al (1997) American Cancer Society guidelines for the early detection of breast cancer: update 1997. CA Cancer J Clin 47:150–153
Acknowledgements
This research was supported by a grant from the National Cancer Institute (5R03CA101493). We thank Berta M Geller for her suggestions about the material’s content and presentation.
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Goel, A., Littenberg, B. & Burack, R.C. The association between the pre-diagnosis mammography screening interval and advanced breast cancer. Breast Cancer Res Treat 102, 339–345 (2007). https://doi.org/10.1007/s10549-006-9334-5
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DOI: https://doi.org/10.1007/s10549-006-9334-5