Skip to main content
SpringerLink
Log in

Assessment of coronary artery by prospective ECG-triggered 256 multi-slice CT on children with congenital heart disease

  • Original Paper
  • Published:
The International Journal of Cardiovascular Imaging Aims and scope Submit manuscript

Abstract

This study aims to investigate the imaging quality and radiation dose of prospective ECG-triggered 256 multi-slice computer tomography (MSCT) in accessing the coronary artery (CA) in children. Coronary arteries of 149 children were evaluated using prospective ECG-triggered 256 MSCT with the same system settings. A four-point scoring system was applied to study the capability of MSCT in detecting CA in these patients. Signal, noise and contrast-to-noise ratios (CNR) were analyzed to investigate the association of image quality with age. Then, volumetric CT dose index (CTDIvol), dose-length product (DLP), and effective dose (ED) were utilized to study the association of radiation dose with age. The detection rate for original, proximal, middle, distal and the 11 segments of CA was 100, 97, 92, 81 and 92%, respectively; and there was no influence on age during the detection (all, P < 0.05). A negative correlation was found between ED and age (r = −0.664, P < 0.001). Significantly larger EDs were found in younger patients (age: <3 years; 1.2 ± 0.5 and 0.6 ± 0.2 mSv; P < 0.001), while higher DLPs were found in elder patients, although no correlation was found between ages versus DLP (r = 0.092, P = 0.262). Prospective ECG-triggered 256 MSCT has considerable performance for the evaluation of CA in children. However, great caution is needed for children under the age of three in the selection of this examination. Furthermore, the tube current could be further reduced for the examination of children ≥8 years.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Goo HW, Park IS, Ko JK, Kim YH, Seo DM, Yun TJ, Park JJ (2005) Visibility of the origin and proximal course of coronary arteries on non-ECG-gated heart CT in patients with congenital heart disease. Pediatr Radiol 35:792–798

    Article  PubMed  Google Scholar 

  2. Tsai IC, Lee T, Chen MC, Fu YC, Jan SL, Wang CC, Chang Y (2007) Visualization of neonatal coronary arteries on multidetector row CT: ECG-gated versus non-ECG-gated technique. Pediatr Radiol 37:818–825

    Article  PubMed  Google Scholar 

  3. Sabri N (1994) Complications of cardiac catheterization, coronary angiography, and coronary interventions. J Invasive Cardiol 6:300–305

    CAS  PubMed  Google Scholar 

  4. Bacher K, Bogaert E, Lapere R, De Wolf D, Thierens H (2005) Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization. Circulation 111:83–89

    Article  PubMed  Google Scholar 

  5. Thomas KE, Wang B (2008) Age-specific effective doses for pediatric MSCT examinations at a large children’s hospital using DLP conversion coefficients: a simple estimation method. Pediatr Radiol 38:645–656

    Article  PubMed  Google Scholar 

  6. Dougeni E, Faulkner K, Panayiotakis G (2012) A review of patient dose and optimisation methods in adult and paediatric CT scanning. Eur J Radiol 81:e665–e683

    Article  CAS  PubMed  Google Scholar 

  7. Karabay KO, Yildiz A, Geceer G, Uysal E, Bagirtan B (2013) The incidence of coronary anomalies on routine coronary computed tomography scans. Cardiovasc J Afr 24:351–354

    Article  PubMed  PubMed Central  Google Scholar 

  8. Roura G, Gomez-Lara J, Ferreiro JL, Gomez-Hospital JA, Romaguera R, Teruel LM, Carreño E, Esplugas E, Alfonso F, Cequier A (2013) Multislice CT for assessing in-stent dimensions after left main coronary artery stenting: a comparison with three dimensional intravascular ultrasound. Heart 99:1106–1112

    Article  PubMed  Google Scholar 

  9. Gabriel J, Klimach S, Lang P, Hildick-Smith D (2015) Should computed tomography angiography supersede invasive coronary angiography for the evaluation of graft patency following coronary artery bypass graft surgery? Interact Cardiovasc Thorac Surg 21(2):231-239

    Article  Google Scholar 

  10. Sheth T, Chan M, Butler C, Chow B, Tandon V, Nagele P, Mitha A, Mrkobrada M, Szczeklik W, Faridah Y, Biccard B, Stewart LK, Heels-Ansdell D, Devereaux PJ, Coronary Computed Tomographic Angiography and Vascular Events in Noncardiac Surgery Patients Cohort EvaluationStudy Investigators (2015) Prognostic capabilities of coronary computed tomographic angiography before non-cardiac surgery: prospective cohort study. BMJ 350:h1907

    Article  PubMed  PubMed Central  Google Scholar 

  11. Pache G, Grohmann J, Bulla S, Arnold R, Stiller B, Schlensak C, Langer M, Blanke P (2011) Prospective electrocardiography-triggered CT angiography of the great thoracic vessels in infants and toddlers with congenital heart disease: feasibility and image quality. Eur J Radiol 80:e440–e445

    Article  PubMed  Google Scholar 

  12. Ben Saad M, Rohnean A, Sigal-Cinqualbre A, Adler G, Paul JF (2009) Evaluation of image quality and radiation dose of thoracic and coronary dual-source CT in 110 infants with congenital heart disease. Pediatr Radiol 39:668–676

    Article  PubMed  Google Scholar 

  13. Ait-Ali L, Andreassi MG, Foffa I, Spadoni I, Vano E, Picano E (2010) Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease. Heart 96:269–274

    Article  PubMed  Google Scholar 

  14. Cheng Z, Wang X, Duan Y, Wu L, Wu D, Chao B, Liu C, Xu Z, Li H, Liang F, Xu J, Chen J (2010) Low-dose prospective ECG-triggered dual-source CT angiography in infants and children with complex congenital heart disease: first experience. Eur Radiol 20:2503–2511

    Article  PubMed  Google Scholar 

  15. Jin KN, Park EA, Shin CI, Lee W, Chung JW, Park JH (2010) Retrospective versus prospective ECG-gated dual-source CT in pediatric patients with congenital heart disease: comparison of image quality and radiation dose. Int J Cardiovasc Imaging 26:63–73

    Article  PubMed  Google Scholar 

  16. Wolf F, Leschka S, Loewe C, Homolka P, Plank C, Schernthaner R (2010) Coronary artery stent imaging with 128-slice dual-source CT using high-pitch spiral acquisition in a cardiac phantom: comparison with the sequential and low-pitch spiral mode. Eur Radiol 20:2084–2091

    Article  PubMed  Google Scholar 

  17. Ghoshhajra BB, Lee AM, Engel LC, Celeng C, Kalra MK, Brady TJ (2014) Radiation dose reduction in pediatric cardiac computed tomography: experience from a tertiary medical center. Pediatr Cardiol 35:171–179

    Article  PubMed  Google Scholar 

  18. Klink T, Müller G, Weil J, Dodge-Khatami A, Adam G, Bley TA (2012) Cardiovascular computed tomography angiography in newborns and infants with suspected congenital heart disease: retrospective evaluation of low-dose scan protocols. Clin Imaging 36:746–753

    Article  PubMed  Google Scholar 

  19. Huang MP, Liang CH, Zhao ZJ, Liu H, Li JL, Zhang JE (2011) Evaluation of image quality and radiation dose at prospective ECG-triggered axial 256-slice multi-detector CT in infants with congenital heart disease. Pediatr Radiol 41:858–866

    Article  PubMed  Google Scholar 

  20. Al-Mousily F, Shifrin RY, Fricker FJ, Feranec N, Quinn NS, Chandran A (2011) Use of 320-detector computed tomographic angiography for infants and young children with congenital heart disease. Pediatr Cardiol 32:426–432

    Article  PubMed  Google Scholar 

  21. Goo HW (2010) State-of-the-art CT imaging techniques for congenital heart disease. Korean J Radiol 11:4–18

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported by key project for the Shanghai Committee of Science and Technology Basic Research (12JC1406600, to Kun Sun) and research project of Shanghai Municipal Health and Family planning Commission (201540135, to Liping Yao).

Author information

Authors and Affiliations

  1. Biomedical Engineering Institution Affiliated to Shanghai Jiaotong University, No. 1954 Hua-Shan Road, Xuhui District, Shanghai, 200030, China

    Li-Ping Yao & Kun Sun

  2. Department of Cardiothoracic Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Li-Ping Yao & Li Zhang

  3. Department of Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Hui-Ming Li, Ming Ding & Ling-Wei Yu

  4. Department of Automation, Institute of Image Processing and Pattern Recognition, Shanghai Jiaotong University, Shanghai, 200092, China

    Xin Yang

  5. Department of Pediatric Cardiology, Xinhua hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200240, China

    Kun Sun

  6. Healthcare Department, Philips Research China, No.10, Lane 888, Tian Lin Road, Shanghai, 200233, China

    Xiao-Ming Li

Authors
  1. Li-Ping Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hui-Ming Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ming Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ling-Wei Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xin Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Xiao-Ming Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kun Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kun Sun.

Ethics declarations

Conflict of interest

None of the authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript.

Research involving human participants and/or animals

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yao, LP., Zhang, L., Li, HM. et al. Assessment of coronary artery by prospective ECG-triggered 256 multi-slice CT on children with congenital heart disease. Int J Cardiovasc Imaging 33, 2021–2028 (2017). https://doi.org/10.1007/s10554-017-1150-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10554-017-1150-y

Keywords

Search

Navigation