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Methods for Calculating Coronary Perfusion Pressure During CPR

  • Original Paper
  • Published:
Cardiovascular Engineering

Abstract

Coronary perfusion pressure (CPP) is a major indicator of the effectiveness of cardiopulmonary resuscitation in human and animal research studies, however, methods for calculating CPP differ among research groups. Here we compare the 6 published methods for calculating CPP using the same data set of aortic (Ao) and right atrial (RA) blood pressures. CPP was computed using each of the 6 calculation methods in an anesthetized pig model, instrumented with catheters with Cobe pressure transducers. Aortic and right atrial pressures were recorded continuously during electrically induced ventricular fibrillation and standard AHA CPR. CPP calculated from the same raw data set by the 6 calculation methods ranged from −1 (signifying retrograde blood flow) to 26 mmHg (mean ± SD of 15 ± 11 mmHg). The CPP achieved by standard closed chest CPR is typically reported as 10–20 mmHg. Within a single study the CPP values may be comparable; however, the CPP values for different studies may not be a reliable indicator of the efficacy of a given CPR method. Electronically derived true mean coronary perfusion pressure is arguably the gold standard method for representing coronary perfusion pressure.

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Acknowledgment

Supported in part by National Institutes of Health (NIBIB Grant NGAR2IEBOO1540) and a grant from the Purdue Trask Fund.

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Authors and Affiliations

  1. MED Institute, Inc., 1 Geddes Way, West Lafayette, IN, 47906, USA

    Michael P. Otlewski

  2. Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN, 47907-2032, USA

    Leslie A. Geddes & Michael Pargett

  3. Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN, 47907-1246, USA

    Charles F. Babbs

Authors
  1. Michael P. Otlewski
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  2. Leslie A. Geddes
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  3. Michael Pargett
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  4. Charles F. Babbs
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Correspondence to Michael P. Otlewski.

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Otlewski, M.P., Geddes, L.A., Pargett, M. et al. Methods for Calculating Coronary Perfusion Pressure During CPR. Cardiovasc Eng 9, 98–103 (2009). https://doi.org/10.1007/s10558-009-9079-y

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  • DOI: https://doi.org/10.1007/s10558-009-9079-y

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