Abstract
An efficient, rapid, one-pot synthesis of tetrahydrobenzo[b]pyran is achieved via a three-component reaction of aldehydes, 1,3-diketone, malononitrile in 20% ethanol using anhydrous potassium phosphate as a catalyst at room temperature. The key advantages are the short reaction time, high yields, simple work-up, inexpensive catalyst and purification of products by non-chromatographic methods, i.e. by simple recrystallization from ethanol.
Graphical Abstract
An efficient, rapid, one-pot synthesis of tetrahydrobenzo[b]pyran is achieved via a three-component reaction of aldehydes, dimedone, malononitrile in 20% ethanol using anhydrous potassium phosphate as a catalyst at room temperature. The key advantages are the short reaction time, high yields, simple work-up, inexpensive catalyst and purification of products by non-chromatographic methods, i.e. by simple recrystallization from ethanol.
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Acknowledgments
Authors DMP and KAU thank UGC, New Delhi for financial assistance [F.2-3/2007(Policy/SR)] and for the Research Fellowship, respectively.
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Pore, D.M., Undale, K.A., Dongare, B.B. et al. Potassium Phosphate Catalyzed a Rapid Three-Component Synthesis of Tetrahydrobenzo[b]pyran at Ambient Temperature. Catal Lett 132, 104–108 (2009). https://doi.org/10.1007/s10562-009-0074-0
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DOI: https://doi.org/10.1007/s10562-009-0074-0