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Could Sirtuin Activities Modify ALS Onset and Progression?

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Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a complex etiology. Sirtuins have been implicated as disease-modifying factors in several neurological disorders, and in the past decade, attempts have been made to check if manipulating Sirtuin activities and levels could confer benefit in terms of neuroprotection and survival in ALS models. The efforts have largely focused on mutant SOD1, and while limited in scope, the results were largely positive. Here, the body of work linking Sirtuins with ALS is reviewed, with discussions on how Sirtuins and their activities may impact on the major etiological mechanisms of ALS. Moving forward, it is important that the potentially beneficial effect of Sirtuins in ALS disease onset and progression are assessed in ALS models with TDP-43, FUS, and C9orf72 mutations.

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Acknowledgement

The author is supported by the NUS Graduate School for Integrative Sciences and Engineering, and declares no conflict of interest. The author is grateful to the anonymous reviewers, whose constructive comments and suggestions have greatly improved the manuscript.

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  1. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore, 117597, Singapore

    Bor Luen Tang

  2. NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore

    Bor Luen Tang

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Tang, B.L. Could Sirtuin Activities Modify ALS Onset and Progression?. Cell Mol Neurobiol 37, 1147–1160 (2017). https://doi.org/10.1007/s10571-016-0452-2

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