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Synthesis of 3-deoxy-3β-(3-aminopropoxyamino) derivatives of oleanolic and ursolic acids

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Chemistry of Natural Compounds Aims and scope

3-Deoxy-3β-(3-aminopropoxyamino) derivatives of oleanolic and ursolic acids were synthesized. 3-Deoxy3-(2-cyanoethoxyimino)urs-12-en-28-oic acid was active in vitro with selectivity index SI 30 against papilloma virus (strain HPV-11).

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Acknowledgment

The work was supported financially by the RFBR (Project No. 8–03–00868). We thank the National Institute of Allergy and Infectious Diseases, NIAID, USA, www.niaid-aacf.org) for studying the antiviral activity of 4.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Urals Division, Russian Academy of Sciences, 450054, Ufa, prosp. Oktyabrya, 71, Russia

    G. V. Giniyatullina, O. B. Kazakova & G. A. Tolstikov

Authors
  1. G. V. Giniyatullina
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  2. O. B. Kazakova
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  3. G. A. Tolstikov
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Correspondence to O. B. Kazakova.

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Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 640–641, September–October, 2010.

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Giniyatullina, G.V., Kazakova, O.B. & Tolstikov, G.A. Synthesis of 3-deoxy-3β-(3-aminopropoxyamino) derivatives of oleanolic and ursolic acids. Chem Nat Compd 46, 760–762 (2010). https://doi.org/10.1007/s10600-010-9734-y

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  • DOI: https://doi.org/10.1007/s10600-010-9734-y

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